Device for distributing a flow

Patent metadata

Field	Value
Publication number	US-12264306-B2
Application number	US-201917296711-A
Country	US
Kind code	B2
Filing date	Dec 10, 2019
Priority date	Dec 19, 2018
Publication date	Apr 1, 2025
Grant date	Apr 1, 2025

Abstract

A flow distribution device for bioprocess systems, comprising: ⋅—a flow distribution manifold ( 12; 112; 212; 312 ) comprising: ⋅o at least four fluid connection tubes ( 14 ), wherein each fluid connection tube ( 14 ) comprises a first end ( 18 ) for fluid connection and an opposite second end ( 20 ) ⋅o a central common compartment ( 30; 130; 230; 330 ) to which the second ends ( 20 ) of each of the fluid connection tubes ( 14 ) are connected, whereby the first ends ( 18 ) of each of the fluid connection tubes ( 14 ) can be in fluid communication with the central common compartment ( 30; 130; 230; 330 ) ⋅—at least three pinching members ( 41 ) which are provided in connection with one fluid connection tube ( 14 ) of the flow distribution manifold ( 12; 112; 212; 312 ) each, wherein each of said pinching members ( 41 ) can be controlled into at least a first and a second position, wherein in the first position for each of the pinching members ( 41 ) the pinching member pinches one of the fluid connection tubes ( 14 ) such that fluid flow is prevented between the first end ( 18 ) and the second end ( 20 ) of this fluid connection tube ( 14 ).

First claim

The invention claimed is:

1. A flow distribution device for bioprocess systems, comprising:
a flow distribution manifold comprising:
at least four fluid connection tubes, wherein each fluid connection tube comprises a first end for fluid connection and an opposite second end, and wherein at least three of the fluid connection tubes comprise at least one flexible part which can be compressed for preventing fluid flow between the first and second end of the fluid connection tube; and
a central common compartment to which the second ends of each of the fluid connection tubes are connected, whereby the first ends of each of the fluid connection tubes can be in fluid communication with the central common compartment and wherein the fluid connection tubes are entering the central common compartment from at least three different directions;

wherein said flow distribution device further comprises
at least three pinching members positioned within a cavity surrounding the central compartment which are provided in connection with one fluid connection tube of the flow distribution manifold each, wherein each of said pinching members can be controlled into at least a first and a second position, wherein in the first position for each of the pinching members the pinching member pinches one of the fluid connection tubes such that fluid flow is prevented between the first end and the second end of this fluid connection tube and in the second position the pinching member is provided in a position such that fluid flow is allowed between the first end and the second end of the fluid connection tube; and
wherein a distance from the second end of at least one of the fluid connection tubes to a second end of an adjacent fluid connection tube is smaller than the distance between two pinching members configured for pinching the same two fluid connection tubes.

2. The flow distribution device according to claim 1 , wherein at least five or at least six fluid connection tubes are provided in the flow distribution manifold.

3. The flow distribution device according to claim 1 , wherein the fluid connection tubes are entering the central common compartment from at least four or five different directions.

4. The flow distribution device according to claim 1 , wherein the second ends of the fluid connection tubes are connected to the central common compartment distributed around an enclosing wall of the central common compartment, which enclosing wall is enclosing an inner room of the central common compartment, wherein each of the fluid connection tubes can be in fluid communication with the inner room of the central common compartment and wherein the fluid connection tubes are entering the enclosing wall of the central common compartment from at least three or four or five different directions.

5. The flow distribution device according to claim 1 , wherein distances between the second ends of each of the fluid connection tubes and a central point of the central common compartment is no more than 3 or 2 or 1 times an inner diameter of the fluid connection tubes or wherein a distance between the second end of each of the fluid connection tubes and a central point of the central common compartment is substantially the same for each fluid connection tube.

6. The flow distribution device according to claim 1 , wherein the flow distribution device comprises either the same number of pinching members as the number of fluid connection tubes provided in the flow distribution manifold or one less, wherein one pinching member is provided in connection with each fluid connection tube or with each fluid connection tube except one, whereby either all fluid connection tubes or all except one can be pinched by a pinching member.

7. The flow distribution device according to claim 1 , wherein said flow distribution manifold is a single-use component.

8. The flow distribution device according to claim 1 , wherein said pinching members are configured for being controlled by a connected control system, whereby the positions of the pinching members can be controlled such that the first end of one of the fluid connection tubes can be fluidly connected with the first end of another one of the fluid connection tubes.

9. The flow distribution device according to claim 1 , further comprising a holder for the flow distribution manifold, wherein said holder is configured for holding said flow distribution manifold in relation to the pinching members which can protrude into an interior of the holder and pinch said fluid connection tubes.

10. A bioprocess separation system comprising a separation device and at least one flow distribution device according to claim 1 connected to an inlet and/or an outlet of the separation device.

11. The bioprocess separation system according to claim 10 , wherein the flow distribution device is connected to an inlet of the separation device, wherein one fluid connection tube of the flow distribution device is connected to the inlet of the separation device and at least three fluid connection tubes of the flow distribution device are connected to different fluid sources comprising fluids to be fed to the separation device.

12. The bioprocess separation system according to claim 10 , wherein a flow distribution device is connected to an outlet of the separation device, wherein one fluid connection tube of the flow distribution device is connected to the outlet of the separation device and at least three fluid connection tubes of the flow distribution device are connected to different fraction collectors collecting different fractions from the separation device.

13. The bioprocess separation system according to claim 10 , wherein the bioprocess separation system comprises a reusable part comprising the pinching members of the flow distribution device and at least one pump head and a single-use part comprising a single use flow path comprising the flow distribution manifold of the flow distribution device and the separation device.

Assignees

• Cytiva Sweden Ab

Inventors

• Olovsson Bjorn
• Lundin Andreas
• Gebauer Klaus
• Francois Tim
• Erickson Kerstin

Classifications

• C12M23/28

  disposable or single use · CPC title

• C12M23/26 Primary

  flexible (flexible containers for laboratory use B01L3/505) · CPC title

• C12M29/00

  Means for introduction, extraction or recirculation of materials, e.g. pumps (pumps per se F04B) · CPC title

• C12M23/40 Primary

  Manifolds; Distribution pieces (fluid transfer means B01L3/563) · CPC title