Micro-machined filter for magnetic particles
US-11161066-B2 · Nov 2, 2021 · US
US12263423B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-12263423-B2 |
| Application number | US-202318318762-A |
| Country | US |
| Kind code | B2 |
| Filing date | May 17, 2023 |
| Priority date | Sep 13, 2018 |
| Publication date | Apr 1, 2025 |
| Grant date | Apr 1, 2025 |
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A method for filtering magnetic particles includes spinning a filter including a plurality of pores within a substrate. The method further includes applying, subsequent to spinning the filter, an external magnetic field to the filter. The method includes disposing a solution including a first particle and a second particle onto the filter. The first particle includes a magnetic particle of interest. The method further includes separating the first particle from the second particle by capturing the first particle within a pore of the plurality of pores within the substrate.
Opening claim text (preview).
What is claimed is: 1. A filter system for filtering magnetic particles, the filter system comprising: a micro-machined filter comprising: a plurality of pores within a substrate; and a magnetic liner arranged on sidewalls and a bottommost surface of pores of the plurality of pores; a coating directly on the magnetic liner, the coating comprising a ligand for the magnetic particle of interest, the ligand positioned such that the magnetic liner is between the ligand and the sidewalls or bottommost surface of the pores; and wherein a pore of the plurality of pores has a width that is greater than a magnetic particle of interest, such that the magnetic particle of interest binds to the magnetic liner within the pore. 2. The filter system of claim 1 , wherein the substrate is a semiconductor material. 3. The filter system of claim 2 , wherein the semiconductor material is silicon. 4. The filter system of claim 1 , wherein the substrate is a dielectric material. 5. The filter system of claim 4 , wherein the dielectric material is glass. 6. The filter system of claim 1 , wherein the substrate is a non-magnetic material. 7. The filter system of claim 1 , wherein the magnetic particle of interest binds to the ligand. 8. The filter system of claim 1 , wherein the magnetic liner comprises iron, nickel, cobalt, or an alloy thereof. 9. The filter system of claim 1 , wherein the magnetic particle comprises iron, nickel, cobalt, or an alloy thereof. 10. The filter system of claim 1 , wherein pores of the plurality of pores have a plurality of widths. 11. The filter system of claim 1 , further comprising a chamber coupled to the micro-machined filter. 12. The filter system of claim 11 , wherein the chamber comprises a surface for spinning the micro-machined filter about an axis arranged substantially perpendicular to the surface. 13. The filter system of claim 12 , wherein the chamber is capable of adjusting a spin speed of the micro-machined filter from about 10 revolutions per minute (RPM) to about 50,000 RPM at a spin acceleration of about 10 to about 5000 RPM per second.
disposed at the outer circumference of a recipient · CPC title
Glass or glassy material · CPC title
Other shaped material, e.g. perforated or porous sheets · CPC title
of inorganic material, e.g. asbestos paper, metallic filtering material of non-woven wires (porous ceramic material {C04B38/00} ; sintering metals C22C1/04; {making porous sintered metal bodies B22F3/10, honeycomb filters B01D46/2418, materials used for filtering exhaust gases of an internal combustion engine F01N3/022, ceramic honeycomb structures C04B38/0006}) · CPC title
Magnetic separation whereby the particles are suspended in a liquid · CPC title
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