Filling nozzle

Patent metadata

Field	Value
Publication number	US-12258162-B2
Application number	US-202418441090-A
Country	US
Kind code	B2
Filing date	Feb 14, 2024
Priority date	May 28, 2018
Publication date	Mar 25, 2025
Grant date	Mar 25, 2025

Abstract

The present invention provides a filling nozzle obtained by using a resin selected from a cycloolefin polymer and a cycloolefin copolymer, or a filling nozzle including a tubular passage for supplying a pharmaceutical solution, and a filling port disposed at a lower end of the tubular passage, in which the tubular passage and the filling port have a circular peripheral cross-section, and an inner diameter of the passage of the filling port is larger than an inner diameter of the tubular passage disposed on an upstream side.

First claim

The invention claimed is:

1. A filling nozzle, comprising a nozzle body having a tubular passage for supplying a pharmaceutical solution, and a filling port having a passage formed continuously to a lower end of the tubular passage, for discharging the pharmaceutical solution from a tip of the filling port,
wherein an inner diameter of the tubular passage is 1.0 to 5.0 mm, and a length in the length direction of the filling nozzle is 10.0 to 300.0 mm, and
wherein the filling nozzle is formed by using a resin having a water contact angle of 80 to 94 degrees, and the resin is selected from the group consisting of a cycloolefin polymer, a cycloolefin copolymer, and polypropylene.

2. The filling nozzle according to claim 1 , wherein the inner diameter of the tubular passage is 1.0 to 3.0 mm.

3. The filling nozzle according to claim 1 , wherein the tubular passage has a constant inner diameter as a whole.

4. The filling nozzle according to claim 1 , wherein the resin is selected from a cycloolefin copolymer that is a copolymer of a cyclic olefin and an olefin, a cycloolefin ring-opening polymer, and a hydrogenated product of the cycloolefin ring-opening polymer.

5. The filling nozzle according to claim 1 , wherein the resin is an ethylene-norbornene copolymer.

6. The filling nozzle according to claim 5 , wherein the ethylene-norbornene copolymer contains a repeating structure derived from addition polymerization of norbornene.

7. The filling nozzle according to claim 1 , wherein the resin is selected from a norbornene ring-opening polymer that may be substituted with C1-6 alkyl, and a hydrogenated product of the ring-opening polymer.

8. A production method for a liquid pharmaceutical formulation, comprising filling a pharmaceutical solution in a vessel by using the filling nozzle according to claim 1 .

9. The production method according to claim 8 , wherein an active ingredient contained in the pharmaceutical solution is an antibody.

Assignees

• Chugai Pharmaceutical Co Ltd

Inventors

• Nishizawa Shaw

Classifications

• B65B3/04

  Methods of, or means for, filling the material into the containers or receptacles · CPC title

• B65B3/003 Primary

  Filling medical containers such as ampoules, vials, syringes or the like · CPC title

• B05B15/525

  by increasing the cross section of the discharge openings · CPC title

• B05B15/65

  Mounting arrangements for fluid connection of the spraying apparatus or its outlets to flow conduits · CPC title

• A61K2039/505

  comprising antibodies · CPC title