Filling nozzle

Patent metadata

Field	Value
Publication number	US-11708186-B2
Application number	US-201917059342-A
Country	US
Kind code	B2
Filing date	May 28, 2019
Priority date	May 28, 2018
Publication date	Jul 25, 2023
Grant date	Jul 25, 2023

Abstract

The present invention provides a filling nozzle obtained by using a resin selected from a cycloolefin polymer and a cycloolefin copolymer, or a filling nozzle including a tubular passage for supplying a pharmaceutical solution, and a filling port disposed at a lower end of the tubular passage, in which the tubular passage and the filling port have a circular peripheral cross-section, and an inner diameter of the passage of the filling port is larger than an inner diameter of the tubular passage disposed on an upstream side.

First claim

The invention claimed is:

1. A filling nozzle, comprising a nozzle body having a tubular passage for supplying a pharmaceutical solution, and a filling port having a passage formed continuously to a lower end of the tubular passage, for discharging the pharmaceutical solution from a tip of the filling port,
wherein the tubular passage of the nozzle body and the passage of the filling port have a circular peripheral cross-section, and an inner diameter of the passage of the filling port is larger than an inner diameter of the tubular passage disposed on an upstream side, and
the filling nozzle is formed by using a material having a water contact angle of 80 to 94 degrees.

2. The filling nozzle according to claim 1 , wherein the tubular passage is connected to the passage of the filling port via an inclined portion having an inner diameter increasing in a downstream direction.

3. The filling nozzle according to claim 1 , wherein the inner diameter of the passage of the filling port in a connecting portion to the tubular passage or an inclined portion is larger than an inner diameter of the connecting portion to the tubular passage or the inclined portion.

4. The filling nozzle according to claim 1 , wherein the material is a resin selected from a cycloolefin polymer and a cycloolefin copolymer.

5. The filling nozzle according to claim 1 , wherein the material is selected from a cycloolefin copolymer that is a copolymer of a cyclic olefin and an olefin, a cycloolefin ring-opening polymer, and a hydrogenated product of the cycloolefin ring-opening polymer.

6. The filling nozzle according to claim 1 wherein the material is an ethylene-norbornene copolymer.

7. The filling nozzle according to claim 6 , wherein the ethylene-norbornene copolymer contains a repeating structure derived from additional polymerization of norbornene.

8. The filling nozzle according to claim 1 , wherein the material is selected from a norbornene ring-opening polymer and a hydrogenated product of the ring-opening polymer.

9. A production method for a liquid pharmaceutical formulation, comprising a step of filling a pharmaceutical solution in a vessel by using the filling nozzle according to claim 1 .

10. The production method according to claim 9 , wherein an active ingredient contained in the pharmaceutical solution is an antibody.

11. A liquid pharmaceutical filling device, including the filling nozzle according to claim 1 .

12. The filling nozzle according to claim 1 , in which the length of the passage of the filling port is 1 to 10 mm, the inner diameter of the tubular passage of the filling nozzle is 1 to 5 mm, and the ratio of the length of the filling port in the length direction of the filling nozzle to the inner diameter at the end of the filling port is 0.7 to 1.8.

13. The filling nozzle according to claim 8 , wherein the ring-opening polymer is substituted with a C 1-6 alkyl.

14. The filling nozzle of claim 1 , wherein the filling nozzle comprises a pharmaceutical composition comprising an antibody at a concentration between 100 mg/mL and 250 mg/mL.

15. A filling nozzle, comprising a nozzle body having a tubular passage for supplying a pharmaceutical solution, and a filling port formed at a lower end of the tubular passage, for discharging the pharmaceutical solution from the filling port, in which an angle of a surface of a lower end of the filling port against a vertical direction to a nozzle length direction is 0 to 75 degrees,
wherein the filling nozzle is formed by using, as a material, a resin selected from a cycloolefin polymer and a cycloolefin copolymer having a water contact angle of 80 to 94 degrees.

16. The filling nozzle according to claim 15 , wherein the material is selected from a cycloolefin copolymer that is a copolymer of a cyclic olefin and an olefin, a cycloolefin ring-opening polymer, and a hydrogenated product of the cycloolefin ring-opening polymer.

17. The filling nozzle according to claim 15 , wherein the material is an ethylene-norbornene copolymer.

18. The filling nozzle according to claim 17 , wherein the ethylene-norbornene copolymer contains a repeating structure derived from additional polymerization of norbornene.

19. The filling nozzle according to claim 15 , in which an inner diameter of the tubular passage is 0.6 to 5.0 mm, 0.8 to 4.0 mm, or 1.0 to 3.0 mm.

20. The filling nozzle according to claim 15 , in which a difference between an outer diameter and an inner diameter of the tubular passage of the filling nozzle is 5 mm or less, 0.1 to 3.0 mm, or 0.2 to 2.0 mm.

21. The filling nozzle according to claim 15 , in which an angle of a surface of a lower end of the filling port against a vertical direction to a nozzle length direction is 0 to 60 degrees, or 0 to 45 degrees.

22. A liquid pharmaceutical filling device, including the filling nozzle according to claim 15 .

23. The filling nozzle according to claim 15 , in which the length of the passage of the filling port is 1 to 10 mm, the inner diameter of the tubular passage of the filling nozzle is 1 to 5 mm, and the ratio of the length of the filling port in the length direction of the filling nozzle to the inner diameter at the end of the filling port is 0.7 to 1.8.

Assignees

• Chugai Pharmaceutical Co Ltd

Inventors

• Nishizawa Shaw

Classifications

• B65B39/00 Primary

  Nozzles, funnels or guides for introducing articles or materials into containers or wrappers · CPC title

• B05B15/525

  by increasing the cross section of the discharge openings · CPC title

• B05B15/65

  Mounting arrangements for fluid connection of the spraying apparatus or its outlets to flow conduits · CPC title

• B65B3/003 Primary

  Filling medical containers such as ampoules, vials, syringes or the like · CPC title

• B65B3/04

  Methods of, or means for, filling the material into the containers or receptacles · CPC title