Nucleic acid molecules encoding binding proteins for gastric inhibitory peptide receptor (GIPR)

Patent metadata

Field	Value
Publication number	US-12252540-B2
Application number	US-202117332578-A
Country	US
Kind code	B2
Filing date	May 27, 2021
Priority date	Dec 23, 2015
Publication date	Mar 18, 2025
Grant date	Mar 18, 2025

Abstract

Methods of treating metabolic diseases and disorders using an antigen binding protein specific for the GIPR polypeptide are provided. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy. In certain embodiments the antigen binding protein is administered in combination with a GLP-1 receptor agonist.

First claim

What is claimed is:

1. A nucleic acid molecule encoding an antibody selected from the group consisting of:
a) an antibody comprising a CDRL1, a CDRL2, a CDRL3, a CDRH1, a CDRH2, and a CDRH3, wherein said CDRL1 comprises SEQ ID NO: 702; said CDRL2 comprises SEQ ID NO: 859; said CDRL3 comprises SEQ ID NO: 1016; said CDRH1 comprises SEQ ID NO: 1173; said CDRH2 comprises SEQ ID NO: 1330; and said CDRH3 comprises SEQ ID NO: 1487;
b) an antibody comprising a light chain variable region comprising SEQ ID NO: 74 and a heavy chain variable region comprising SEQ ID NO: 231; and
c) an antibody comprising a light chain comprising SEQ ID NO: 388 and a heavy chain comprising SEQ ID NO: 545.

2. The nucleic acid molecule according to claim 1 , wherein said nucleic acid molecule is operably linked to a control sequence.

3. A vector comprising a nucleic acid molecule according to claim 2 .

4. A host cell comprising the nucleic acid molecule according to claim 3 .

5. A method of making the antibody, comprising the step of preparing said antibody from a host cell of claim 4 .

Assignees

• Amgen Inc

Inventors

• Yie Junming
• Shi Donghui
• Lloyd David J
• Wang Jinghong
• Sivits Jr Glenn N
• Veniant-Ellison Murielle M
• Komorowski Renee
• Agrawal Neeraj
• Bates Darren L
• Clavette Brandon C P
• Foltz Ian N
• Ho Shu-Yin
• Murawsky Christopher
• Min Xiaoshan
• Wang Zhulun

Classifications

• A61P3/00

  Drugs for disorders of the metabolism (of the blood or the extracellular fluid A61P7/00) · CPC title

• A61P3/08

  for glucose homeostasis (pancreatic hormones A61P5/48) · CPC title

• A61K38/1703

  from vertebrates · CPC title

• A61P3/06

  Antihyperlipidemics · CPC title

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title