Bridged tricyclic carbamoylpyridone compounds and their pharmaceutical use

Patent metadata

Field	Value
Publication number	US-12227520-B2
Application number	US-202218050650-A
Country	US
Kind code	B2
Filing date	Oct 28, 2022
Priority date	Mar 22, 2019
Publication date	Feb 18, 2025
Grant date	Feb 18, 2025

Abstract

Compounds for use in treating or preventing human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following formula (I):

including stereoisomers and pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , L, W 1 , W 2 , X, Y, and Z are as defined herein. Methods associated with the preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

First claim

We claim:

1. A compound selected from the group consisting of:

or a pharmaceutically acceptable salt thereof.

2. A compound selected from the group consisting of:

or a pharmaceutically acceptable salt thereof.

3. A pharmaceutical composition comprising a therapeutically effective amount of a compound of claim 1 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.

4. The pharmaceutical composition of claim 3 , further comprising one, two, three, or four additional therapeutic agents.

5. The pharmaceutical composition of claim 4 , wherein the additional therapeutic agent or agents are anti-HIV agents.

6. A pharmaceutical composition comprising a therapeutically effective amount of a compound of claim 2 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.

7. The pharmaceutical composition of claim 6 , further comprising one, two, three, or four additional therapeutic agents.

8. The pharmaceutical composition of claim 7 , wherein the additional therapeutic agent or agents are anti-HIV agents.

Assignees

• Gilead Sciences Inc

Inventors

• Chu Hang
• Gonzalez Buenrostro Ana Z
• Guo Hongyan
• Han Xiaochun
• Jiang Lan
• Li Jiayao
• Mitchell Michael L
• Pyun Hyung-Jung
• Schroeder Scott D
• Schwarzwalder Gregg M
• Shapiro Nathan D
• Shivakumar Devleena M
• Wu Qiaoyin
• Yang Hong
• Zhang Jennifer R

Classifications

• A61P31/18 Primary

  for HIV · CPC title

• C07D513/18

  Bridged systems · CPC title

• C07D495/22

  in which the condensed system contains four or more hetero rings · CPC title

• C07D498/22

  in which the condensed system contains four or more hetero rings · CPC title

• C07D471/22

  in which the condensed systems contains four or more hetero rings · CPC title