Methods and compounds for treating Paramyxoviridae virus infections

Patent metadata

Field	Value
Publication number	US-10065958-B2
Application number	US-201514613719-A
Country	US
Kind code	B2
Filing date	Feb 4, 2015
Priority date	Jul 22, 2010
Publication date	Sep 4, 2018
Grant date	Sep 4, 2018

Abstract

Provided are methods for treating Paramyxoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula I:

wherein the 1′ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Human parainfluenza and Human respiratory syncytial virus infections.

First claim

What is claimed is:

1. A compound that is

or a pharmaceutically acceptable salt or ester thereof.

2. A compound

Assignees

• Gilead Sciences Inc

Inventors

• Mackman Richard L
• Parrish Jay P
• Ray Adrian S
• Theodore Dorothy Agnes

Classifications

• A61P31/14

  for RNA viruses · CPC title

• A61P31/16

  for influenza or rhinoviruses · CPC title

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P31/12

  Antivirals · CPC title

• Y02A50/30

  Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change · CPC title