Anti-infection fluidic channel

Patent metadata

Field	Value
Publication number	US-12220539-B2
Application number	US-202418896646-A
Country	US
Kind code	B2
Filing date	Sep 25, 2024
Priority date	Mar 13, 2023
Publication date	Feb 11, 2025
Grant date	Feb 11, 2025

Abstract

Systems and methods for altering the geometry of a fluid channel to prevent upstream mobility of bacteria, using angled obstacles on the interior of the channel that among other things creates vortices that restrict the mobility. An optimized geometry can be realized by an artificial intelligence algorithm or similar methods based on performance of various configurations of obstacle parameters.

First claim

The following are claimed:

1. A method of making a catheter having a urine flow direction, the method comprising:
providing a catheter tube with an inner channel;
providing a plurality of protuberances on an interior surface of the inner channel, each of the protuberances having a first side facing into the flow direction at a first angle from the interior surface and a second side facing away from the flow direction at a second angle from the interior surface and a vertex between the first side and the second side and a base length from where the first side connects to the interior surface to where the second side connects to the interior surface, each of the plurality of protuberances being configured to create vortices during a flow of fluid in the urine flow direction;
the first angle being different from the second angle, such that each protuberance has an asymmetrical profile and wherein the first angle is greater than 90 degrees and the second angle is less than 90 degrees; and
the base length of each of the plurality of protuberances being less than one half the distance between vertices of adjacent protuberances;
wherein the providing the plurality of protuberances comprises optimizing geometry parameters of the plurality of protuberances by a geometric Fourier neural operator model.

2. The method of claim 1 , wherein the catheter has an outer diameter from 5 to 36 Fr.

3. The method of claim 1 , wherein catheter has a channel width from 1 to 100 mm.

4. The method of claim 3 , wherein each of the plurality of protuberances has a height equal to or less than 30% of the channel width.

5. The method of claim 1 , wherein the providing the plurality of protuberances comprises one or more of: 3D printing, injection molding, extrusion molding, computer numerical control machining, polymer casting, and thermoforming.

6. The method of claim 1 , wherein the plurality of protuberances is composed of silicone rubber, nylon, polyurethane, polyethylene terephthalate, latex, polytetrafluoroethylene, or combinations thereof.

7. The method of claim 1 , wherein the geometric Fourier neural operator model is trained as a surrogate model for a forward fluid and particle dynamics simulation that maps the geometry parameters to a bacteria population function.

Assignees

• California Inst Of Techn

Inventors

• Zhou Tingtao
• Wan Xuan
• Sternberg Paul W
• Daraio Chiara
• Huang Zhengyu
• Li Zongyi
• Peng Zhiwei
• Brady John F
• Anandkumar Animashree

Classifications

• G06N20/00

  Machine learning · CPC title

• A61M2025/006

  having a special surface topography or special surface properties, e.g. roughened or knurled surface · CPC title

• G16H50/50

  for simulation or modelling of medical disorders · CPC title

• G16H30/40

  for processing medical images, e.g. editing · CPC title

• G16H20/40

  relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture · CPC title