Anti-infection fluidic channel

Patent metadata

Field	Value
Publication number	US-12128189-B2
Application number	US-202418604162-A
Country	US
Kind code	B2
Filing date	Mar 13, 2024
Priority date	Mar 13, 2023
Publication date	Oct 29, 2024
Grant date	Oct 29, 2024

Abstract

Systems and methods for altering the geometry of a fluid channel to prevent upstream mobility of bacteria, using angled obstacles on the interior of the channel that among other things creates vortices that restrict the mobility. An optimized geometry can be realized by an artificial intelligence algorithm or similar methods based on performance of various configurations of obstacle parameters.

First claim

The following are claimed:

1. An article comprising a fluidic channel having a flow direction, the article comprising:
a plurality of protuberances on an interior surface of the fluidic channel, each of the protuberances having a first side facing into the flow direction at a first angle from the interior surface and a second side facing away from the flow direction at a second angle from the interior surface and a vertex between the first side and the second side and a base length from where the first side connects to the interior surface to where the second side connects to the interior surface, each of the plurality of protuberances being configured to create vortices during a flow of fluid in the flow direction;
the first angle being different from the second angle, such that each protuberance has an asymmetrical profile and wherein the first angle is greater than 90 degrees and the second angle is less than 90 degrees; and
the base length of each of the plurality of protuberances being less than one fourth the distance between vertices of adjacent protuberances.

2. The article of claim 1 , wherein the asymmetrical profile is a triangular profile.

3. The article of claim 1 , wherein the second side is curved.

4. The article of claim 3 , wherein the second side has a concave curve.

5. The article of claim 1 , wherein the vertex is rounded.

6. The article of claim 1 , wherein a ratio (d/W) of the distance (d) between the vertex to a vertex of a neighboring protuberance to a diameter of the fluidic channel (W) is over 0.3.

7. The article of claim 6 , wherein the ratio is also less than 10.

8. The article of claim 6 , wherein the distance (d) is at least 60 μm.

9. The article of claim 1 , wherein the base length is at least 15 μm.

10. The article of claim 1 , wherein the base length is no more than half the distance between the vertex and a vertex of a neighboring protuberance.

11. The article of claim 1 , wherein a height of the vertex of each protuberance is at least 20 μm from a base of that protuberance, and a ratio of the height to a diameter of the fluidic channel is no more than 0.3.

Assignees

• California Inst Of Techn

Inventors

• Zhou Tingtao
• Wan Xuan
• Sternberg Paul W
• Daraio Chiara
• Huang Zhengyu
• Li Zongyi
• Peng Zhiwei
• Brady John F
• Anandkumar Animashree

Classifications

• G06N20/00

  Machine learning · CPC title

• A61M2025/006

  having a special surface topography or special surface properties, e.g. roughened or knurled surface · CPC title

• G16H50/50

  for simulation or modelling of medical disorders · CPC title

• G16H30/40

  for processing medical images, e.g. editing · CPC title

• G16H20/40

  relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture · CPC title