Diagnostically useful results in real time

Patent metadata

Field	Value
Publication number	US-12217872-B2
Application number	US-202318182285-A
Country	US
Kind code	B2
Filing date	Mar 10, 2023
Priority date	Oct 24, 2012
Publication date	Feb 4, 2025
Grant date	Feb 4, 2025

Abstract

A method and apparatus for vascular assessment are disclosed. The apparatus, in some embodiments, receives, from a medical imaging device, a medical image of a coronary vessel tree of a subject and calculates a plurality of geometric measurements associated with individual portions of a vascular segment of the coronary vessel tree. The apparatus also determines a plurality of resistances associated with the plurality of geometric measurements associated with the individual portions of the vascular segment and determines a plurality of pressure drops across the individual portions of the vascular segment based on the determined resistances and a calculated or estimated blood flow. The apparatus further calculates based on the plurality of pressure drops, a functional index indicative of a presence or an absence of a stenosis within the vascular segment.

First claim

The invention is claimed as follows:

1. A computer-implemented method comprising:
obtaining a plurality of medical images of a coronary vessel tree;
determining first pressure drops associated with the coronary vessel tree, wherein individual pressure drops are associated with individual vessels segments which form the coronary vessel tree;
for a particular vessel segment, adjusting the first pressure drop to revascularize the particular vessel segment and form second pressure drops associated with the coronary vessel tree; and
determining an index indicative of vascular function, based, at least in part, on a comparison between the first pressure drops and the second pressure drops.

2. The method of claim 1 , wherein an individual pressure drop is determined for an individual vessel segment based on resistances associated with the individual vessel segment.

3. The method of claim 1 , wherein an individual pressure drop is determined for an individual segment based on flow information associated with, at least, the individual vessel segment.

4. The method of claim 3 , wherein the individual pressure drop is determined for the individual segment based on flow information associated with a branch in which the individual vessel segment is included.

5. The method of claim 1 , wherein adjusting the first pressure drop to revascularize the particular vessel segment comprises adjusting geometry information associated with the particular vessel segment.

6. The method of claim 1 , wherein the index indicates an effect associated with revascularization of the particular vessel segment.

7. The method of claim 1 , wherein a command is received via a user interface to model an effect associated with revascularization.

8. Non-transitory computer storage media storing instructions that when executed by a system of one or more computers, cause the one or more computers to perform operations comprising:
obtaining a plurality of medical images of a coronary vessel tree;
determining first pressure drops associated with the coronary vessel tree, wherein individual pressure drops are associated with individual vessel segments which form the coronary vessel tree;
for a particular vessel segment, adjusting the first pressure drop to revascularize the particular vessel segment and form second pressure drops associated with the coronary vessel tree; and
determining an index indicative of vascular function, based, at least in part, on a comparison between the first pressure drops and the second pressure drops.

9. The computer storage media of claim 8 , wherein an individual pressure drop is determined for an individual vessel segment based on resistances associated with the individual vessel segment.

10. The computer storage media of claim 8 , wherein an individual pressure drop is determined for an individual segment based on flow information associated with, at least, the individual vessel segment.

11. The computer storage media of claim 10 , wherein the individual pressure drop is determined for the individual segment based on flow information associated with a branch in which the individual vessel segment is included.

12. The computer storage media of claim 8 , wherein adjusting the first pressure drop to revascularize the particular vessel segment comprises adjusting geometry information associated with the particular vessel segment.

13. The computer storage media of claim 8 , wherein the index indicates an effect associated with revascularization of the particular vessel segment.

14. The computer storage media of claim 13 , wherein a command is received via a user interface to model the effect associated with revascularization.

15. A system comprising one or more processors and non-transitory computer storage media storing instructions that when executed by the system of one or more processors, cause the one or more processors to perform operations comprising:
obtaining a plurality of medical images of a coronary vessel tree;
determining first pressure drops associated with the coronary vessel tree, wherein individual pressure drops are associated with individual vessels segments which form the coronary vessel tree;
for a particular vessel segment, adjusting the first pressure drop to revascularize the particular vessel segment and form second pressure drops associated with the coronary vessel tree; and
determining an index indicative of vascular function, based, at least in part, on a comparison between the first pressure drops and the second pressure drops.

16. The system of claim 15 , wherein an individual pressure drop is determined for an individual vessel segment based on resistances associated with the individual vessel segment.

17. The system of claim 15 , wherein an individual pressure drop is determined for an individual segment based on flow information associated with, at least, the individual vessel segment.

18. The system of claim 17 , wherein the individual pressure drop is determined for the individual segment based on flow information associated with a branch in which the individual vessel segment is included.

19. The system of claim 15 , wherein the index indicates an effect associated with revascularization of the particular vessel segment.

20. The system of claim 19 , wherein a command is received via a user interface to model the effect associated with revascularization.

Assignees

• Cathworks Ltd

Inventors

• Lavi Ifat
• Kornowski Ran
• Avrahami Idit
• Benishti Nessi
• Lavi Guy

Classifications

• G06T2211/404

  Angiography · CPC title

• G06T2210/41

  Medical · CPC title

• A61B6/541

  involving acquisition triggered by a physiological signal · CPC title

• A61B6/5217

  extracting a diagnostic or physiological parameter from medical diagnostic data · CPC title

• A61B6/507

  for determination of haemodynamic parameters, e.g. perfusion CT · CPC title