Compositions, methods and kits for treating a contact lens

Patent metadata

Field	Value
Publication number	US-12208159-B2
Application number	US-202217948376-A
Country	US
Kind code	B2
Filing date	Sep 20, 2022
Priority date	Apr 29, 2016
Publication date	Jan 28, 2025
Grant date	Jan 28, 2025

Abstract

Provided herein are fluorinated compounds having chemical structures: (I) where n is 0 or greater, or (II) where m and n are 0 or greater, or an amino acid, a soluble polymer, an oligo(ethylene glycol), a poly(ethylene glycol), or a carbohydrate each fluorinated with perfluorocarbons having the chemical structure (III) where n is 0 or greater. These fluorinated compounds are utilized in contact lenses to impart lipid-resistant, protein-resistant and biofouling-resistant properties, thus reducing discomfort and infection caused by contact lens wear without changing its transmission characteristics. Also provided is an ophthalmic drug delivery system comprising at least one of the compounds described above embedded in the contact lens and a kit to incorporate the ophthalmic into a contact lens. Methods for incorporating these compounds onto a contact lens without affecting transparency and for use in treating an ophthalmologic-associated condition are provided.

First claim

What is claimed is:

1. A modified contact lens, comprising:
a contact lens, wherein the contact lens comprises fluorinated molecules, and wherein the contact lens has at least a 3.7% atomic concentration of fluorinated molecules on surfaces of the contact lens; and
at least one fluorinated compound, wherein the at least one fluorinated compound is attached to the fluorinated molecules in the contact lens through a fluorous interaction to produce the modified contact lens, wherein the at least one fluorinated compound is a fluorinated ophthalmic drug compound having the chemical structure:

wherein n is 0 or greater and m is 0 or greater, and wherein at least 68 nmol of the at least one fluorinated compound are attached to the fluorinated molecules in the modified contact lens.

2. The modified contact lens of claim 1 , wherein the modified contact lens is resistant to microbial agents.

3. The modified contact lens of claim 1 , wherein the modified contact lens maintains transparency.

Assignees

• Univ Houston System

Inventors

• Qin Guoting
• Cai Chengzhi

Classifications

• A61L12/10

  Halogens or compounds thereof · CPC title

• A61K31/496

  Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin · CPC title

• C07D215/56

  with oxygen atoms in position 4 · CPC title

• C07C271/14 Primary

  to carbon atoms of hydrocarbon radicals substituted by halogen atoms or by nitro or nitroso groups · CPC title

• C07C271/12

  to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals · CPC title