System for improved tissue handling and in line analysis of the tissue

Patent metadata

Field	Value
Publication number	US-12196771-B2
Application number	US-201916353705-A
Country	US
Kind code	B2
Filing date	Mar 14, 2019
Priority date	Nov 24, 2010
Publication date	Jan 14, 2025
Grant date	Jan 14, 2025

Abstract

A system for analysis of biopsy samples includes a tissue sample transport mechanism linking a biopsy sample excision tool to a tissue sample holder disposed in a staging area of an analysis unit. The tissue sample is automatically transported from the excision tool to the specimen holder, where the tissue sample is analyzed in the staging area of the analysis unit. The transport mechanism may include tubing and a vacuum source. The tissue sample holder may be configured to slow or temporarily stop a tissue sample for individual analysis, or collect multiple tissue samples for analysis as a group. A tissue sample sorting mechanism may be employed that allows separation of specimens that can be correlated to the analysis.

First claim

What is claimed is:

1. A tissue specimen holder assembly for use in a tissue biopsy system, the tissue specimen holder assembly comprising:
a container base comprising a bottom, a cylindrical sidewall extending from the bottom of the base to a rim defining an open top of the base, and a generally circular stage member that projects from the bottom of the base, the stage member fixedly coupled to the bottom of the base, wherein a diameter of the stage member is smaller than a diameter of the sidewall, such that the base comprises an annular gutter surrounding the stage member, and wherein one or both of the bottom and the cylindrical sidewall of the base comprises a fluid egress port that allows fluid in the annular gutter to flow out of the base;
a tissue storage basket comprising a bottom wall and an outer cylindrical sidewall extending from the bottom wall, the bottom wall including a bottom surface having a center recess and a circumferential planar surface, wherein one or both of the bottom wall and the outer cylindrical sidewall of the tissue storage basket are fluid porous,
wherein the tissue storage basket is sized and shaped for insertion into the base, wherein the tissue storage basket is inserted through the open top of the base and removably seated within the bottom of the base with the center recess of the bottom surface of the tissue storage basket resting on top of the stage member of the base such that the circumferential planar surface of the bottom surface is disposed within the annular gutter, and
wherein the bottom wall and the outer cylindrical sidewall of the tissue storage basket at least partially define one or more tissue sample holding compartments.

2. The tissue specimen holder assembly of claim 1 , the one or more tissue sample holding compartments comprising a plurality of circumferentially spaced tissue holding compartments, the tissue storage basket further comprising respective dividing walls that separate adjacent tissue holding compartments.

3. The tissue specimen holder assembly of claim 2 , wherein the tissue storage basket comprises detectable features and/or indicia configured to aid in identifying respective tissue storage compartments of the tissue storage basket.

4. The tissue specimen holder assembly of claim 3 , wherein the detectable features and/or indicia comprise radiopaque markings.

5. The tissue specimen holder assembly of claim 3 , wherein the detectable features and/or indicia comprise markings visible to a human eye.

6. The tissue specimen holder assembly of claim 2 , wherein the tissue storage basket is configured for being x-ray imaged using a mammography system.

7. The tissue specimen holder assembly of claim 1 , further comprising a cover configured to enclose the open top of the base.

8. The tissue specimen holder assembly of claim 1 , wherein the bottom of the base is configured to receive a drive member therethrough, and wherein the drive member is configured to engage and rotate the tissue storage basket within the base.

9. The tissue specimen holder assembly of claim 1 , further comprising a cover removably secured to the cylindrical sidewall of the base when the tissue storage basket is seated within the base, wherein the cylindrical sidewall of the base includes one or more lugs and the cover includes a bottom end with one or more corresponding recesses such that when the cylindrical sidewall of the base is received within the bottom end of the cover the one or more lugs engage with the one or more corresponding recesses when the cover rotates relative to the base, wherein a top end of the cover defines an inlet port, and wherein the tissue storage basket is rotatable relative to the inlet port and the cylindrical sidewall.

Assignees

• Hologic Inc

Inventors

• Flagle Jacob
• Ang Chia Yee
• Defreitas Kenneth F
• Shaw Ian
• Laviola John
• Perkins Samantha
• Nicoson Zachary R

Classifications

• A61B10/0096

  Casings for storing test samples (A61B10/0038, A61B10/0045 take precedence; preservation of living parts of the human or animal body A01N1/10; containers for retaining a material to be analysed B01L3/50; containers for enzymology or microbiology C12M1/16; swab-sampler being part of enzymology or microbiology container C12M1/30) · CPC title

• A61B6/4405

  the apparatus being movable or portable, e.g. handheld or mounted on a trolley · CPC title

• A61B10/0275

  with sample notch, e.g. on the side of inner stylet · CPC title

• G01N2035/0481

  Pneumatic tube conveyors; Tube mails; "Rohrpost" · CPC title

• B01L2400/0644

  rotary valves · CPC title