Polymer materials for delivery of short-chain fatty acids to the intestine for applications in human health and treatment of disease

Patent metadata

Field	Value
Publication number	US-12186402-B2
Application number	US-202318303292-A
Country	US
Kind code	B2
Filing date	Apr 19, 2023
Priority date	Apr 17, 2017
Publication date	Jan 7, 2025
Grant date	Jan 7, 2025

Abstract

Provided herein are polymer materials that find use in, for example, delivery of short-chain fatty acids. In particular, polymers are provided that form stable nanoscale structures and release their payload, for example, by cleavage of a covalent bond (e.g., via hydrolysis or enzymatic cleavage). The polymers are useful, for example, for delivery of payloads (e.g., SCFAs) to the intestine for applications in health and treatment of disease, and have broad applicability in diseases linked to changes in the human microbiota including inflammatory, autoimmune, allergic, metabolic, and central nervous system diseases, among others.

First claim

What is claimed is:

1. A system comprising a supramolecular assembly of polymers having the structure:

wherein each Y is independently selected from:
(i) hydrophilic side-chain, and
(ii) a side chain of the formula:

and
wherein the polymers comprise at least one of each of (i) and (ii).

2. The system of claim 1 , wherein the hydrophilic side-chain is of the formula:

3. The system of claim 1 , wherein the polymers are random copolymers, wherein the side chains (i) and (ii) are randomly distibuted.

4. The system of claim 1 , wherein the polymers are block copolymers having the structure:

wherein a and b are collectively 2-900.

5. The system of claim 1 , wherein the supramolecular assembly is a micelle or nanoparticle.

6. A pharmaceutical composition comprising a system of claim 1 and a pharmaceutically-acceptable carrier.

7. A food or nutraceutical composition comprising a system of claim 1 and a pharmaceutically-acceptable carrier.

Assignees

• Univ Chicago

Inventors

• Hubbell Jeffrey A
• Wang Ruyi
• Wilson D Scott
• Nagler Cathryn R
• Plunkett Catherine

Classifications

• C08F2438/03

  Use of a di- or tri-thiocarbonylthio compound, e.g. di- or tri-thioester, di- or tri-thiocarbamate, or a xanthate as chain transfer agent, e.g . Reversible Addition Fragmentation chain Transfer [RAFT] or Macromolecular Design via Interchange of Xanthates [MADIX] · CPC title

• C08F293/005 Primary

  using free radical "living" or "controlled" polymerisation, e.g. using a complexing agent · CPC title

• A61K45/06

  Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca · CPC title

• A61K47/6929

  the form being a nanoparticle, e.g. an immuno-nanoparticle · CPC title

• A61K47/6907

  the form being a microemulsion, nanoemulsion or micelle · CPC title