Nutritional compositions containing magnesium threonate and uses thereof

Patent metadata

Field	Value
Publication number	US-9301966-B2
Application number	US-201313739813-A
Country	US
Kind code	B2
Filing date	Jan 11, 2013
Priority date	Jan 11, 2013
Publication date	Apr 5, 2016
Grant date	Apr 5, 2016

Abstract

The present disclosure relates to nutritional composition(s) comprising a carbohydrate source, a protein source, a fat source and magnesium threonate. Magnesium threonate may provide neurological health benefits when consumed. The disclosure further relates to methods of promoting neurological health by providing a nutritional composition comprising magnesium threonate. Additionally, the disclosure relates to methods of promoting GI tolerance in a pediatric subject by providing a nutritional composition comprising magnesium threonate.

First claim

What is claimed is:

1. A nutritional composition comprising per 100 kcal:
(i) between about 6 g and about 22 g of a carbohydrate source,
(ii) between about 1 g and about 7 g of a protein source,
(iii) between about 1 g and about 10.3 g of a fat source, and
(iv) about 4.9 mg/100 kcal to about 45 mg/100 kcal of magnesium threonate.

2. The nutritional composition of claim 1 , further comprising a prebiotic.

3. The nutritional composition of claim 2 , wherein the prebiotic is selected from the group consisting of polydextrose and galacto-oligosaccharide.

4. The nutritional composition of claim 1 , further comprising DHA from about 5 mg to about 75 mg.

5. The nutritional composition of claim 1 , further comprising a probiotic from about 1×10 4 cfu to about 1.5×10 10 cfu.

6. The nutritional composition of claim 1 , wherein the nutritional composition is an infant formula.

7. A method of promoting GI tolerance in a pediatric subject by providing a nutritional composition comprising between about 6 g and about 22 g of a carbohydrate source, between about 1 g and about 7 g of a protein source, between about 1 g and about 10.3 g of a fat source, and between about 4.9 mg and about 45 mg of magnesium threonate per 100 kcal of nutritional composition to a pediatric subject, wherein the occurrence of oxidative neuronal cell death is reduced.

8. The method of claim 7 , wherein the nutritional composition comprises per 100 kcal:
(i) between about 6 g and about 22 g of a carbohydrate source;
(ii) between about 1 g and about 7 g of a protein source;
(iii) between about 1 g and about 10.3 g of a fat source;
(iv) between about 0.1 mg and about 1 mg of polydextrose; and
(v) between about 0.1 mg and about 1 mg of galacto-oligosaccharide.

9. The method of claim 7 , wherein the nutritional composition comprises magnesium threonate from about 6 mg/100 kcal to about 26 mg/100 kcal.

10. The method of claim 7 , wherein the nutritional composition comprises magnesium threonate from about 15 mg/100 kcal to about 25 mg/100 kcal.

11. The method of claim 7 , wherein the nutritional composition further comprises DHA.

12. The method of claim 7 , wherein the nutritional composition is an infant formula.

13. A method of promoting neurological health in a pediatric subject by providing to a pediatric subject a nutritional composition comprising between about 6 g and about 22 g of a carbohydrate source, between about 1 g and about 7 g of a protein source, between about 1 g and about 10.3 g of a fat source, and between about 4.9 mg and about 45 mg magnesium threonate per 100 kcal, wherein the occurrence of oxidative neuronal cell death is reduced.

14. The method of claim 13 , wherein the nutritional composition comprises magnesium threonate from about 6 mg/100 kcal to about 26 mg/100 kcal.

15. The method of claim 13 , wherein the nutritional composition comprises magnesium threonate from about 15 mg/100 kcal to about 25 mg/100 kcal.

16. The method of claim 13 , wherein the nutritional composition further comprises DHA.

17. The method of claim 13 , wherein the nutritional composition is an infant formula.

Assignees

• Mead Johnson Nutrition Co

Inventors

• Berg Brian

Classifications

• A61K31/20

  having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids · CPC title

• A61K35/20

  Milk; Whey; Colostrum · CPC title

• A61K31/191

  having two or more hydroxy groups, e.g. gluconic acid · CPC title

• A23L33/16

  Inorganic salts, minerals or trace elements · CPC title

• A61K31/202

  having three or more double bonds, e.g. linolenic (eicosanoids, e.g. leukotrienes A61K31/557) · CPC title