Process for making beta 3 agonists and intermediates
US-11708371-B2 · Jul 25, 2023 · US
Process for preparing beta 3 agonists and intermediates
US12180219B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-12180219-B2 |
| Application number | US-202418649712-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 29, 2024 |
| Priority date | Mar 15, 2013 |
| Publication date | Dec 31, 2024 |
| Grant date | Dec 31, 2024 |
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- Title
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Abstract
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The application is directed to efficient and economical processes as described in more detail below for the preparation of the beta 3 agonists of the formula of I-7 and intermediate compounds that can be used for making these agonists. The present disclosure relates to a process for making beta-3 agonists and intermediates using ketoreductase (KRED) biocatalyst enzymes and methods of using the biocatalysts.
First claim
Opening claim text (preview).
What is claimed is: 1. A crystalline form of Compound I-7: characterized by a powder X-ray diffraction (XRPD) pattern comprising °2θ peaks at about 5.5, 8.7, and 11.0. 2. The crystalline form of Compound I-7 of claim 1 , wherein the crystalline form is characterized by the XRPD pattern further comprising a °2θ peak at about 17.5. 3. The crystalline form of Compound I-7 of claim 1 , wherein the crystalline form is characterized by the XRPD pattern further comprising a °2θ peak at about 22.7. 4. The crystalline form of Compound I-7 of claim 1 , wherein the crystalline form is characterized by the XRPD pattern further comprising °2θ peaks at about 17.5 and 22.7. 5. The crystalline form of Compound I-7 of claim 1 , characterized by an XRPD pattern as shown in FIG. 2 . 6. The crystalline form of Compound I-7 of claim 1 which is anhydrous. 7. The crystalline form of Compound I-7 of claim 1 , wherein the crystalline form is characterized by an XRPD pattern comprising the following reflections with d-spacing: Position [°2 Theta] d-spacing [Å] 5.4897 16.09873 8.7494 10.10683 11.0426 8.01261 16.4521 5.38818 16.6518 5.32402 17.4975 5.06857 18.853 4.7071 21.2176 4.18756 21.7532 4.08564 22.7425 3.9101 8. A composition comprising the crystalline form of Compound I-7 of claim 1 .
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Classifications
Nitrogen as only ring hetero atom · CPC title
Oxygen or sulfur atoms · CPC title
containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton · CPC title
with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms · CPC title
Crystalline forms, e.g. polymorphs · CPC title
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- What does patent US12180219B2 cover?
- The application is directed to efficient and economical processes as described in more detail below for the preparation of the beta 3 agonists of the formula of I-7 and intermediate compounds that can be used for making these agonists. The present disclosure relates to a process for making beta-3 agonists and intermediates using ketoreductase (KRED) biocatalyst enzymes and methods of using the …
- Who is the assignee on this patent?
- Merck Sharp & Dohme Llc
- What technology area does this patent fall under?
- Primary CPC classification C07D487/04. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Dec 31 2024 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 12 related publications on this page (citations in our corpus or others sharing the same primary CPC).