Process for making beta 3 agonists and intermediates
US-10577316-B2 · Mar 3, 2020 · US
Process for making beta 3 agonists and intermediates
US10899771B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10899771-B2 |
| Application number | US-201916590180-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 1, 2019 |
| Priority date | Oct 27, 2011 |
| Publication date | Jan 26, 2021 |
| Grant date | Jan 26, 2021 |
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- Title
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Abstract
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The present invention is directed to processes for preparing beta 3 agonists of Formula (I) and Formula (II) and their intermediates. The beta 3 agonists are useful in the treatment of certain disorders, including overactive bladder, urinary incontinence, and urinary urgency.
First claim
Opening claim text (preview).
What is claimed is: 1. A process of making a compound of Formula (II): comprising reacting compound I-11: with compound i-30: in the presence of an acid and a solvent: 2. The process of claim 1 wherein the solvent is selected from the group consisting of MeOH, EtOH, IPA, n-PrOH, MeCN, DMF, DMAc, THF, EtOAc, IPAc, and toluene. 3. The process of claim 1 , wherein the acid is selected from the group consisting of HCl, HBr, HI, HNO 3 , H 2 SO 4 , H 3 PO 4 , TFA, and MeSO 3 H. 4. The process of claim 1 , further comprising adding EDCI to the mixture of compound I-11, compound i-30, and acid.
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ortho- or peri-condensed with heterocyclic rings · CPC title
Radicals substituted by nitrogen atoms, not forming part of a nitro radical · CPC title
with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms · CPC title
1,2,4-Triazoles · CPC title
- C07D487/04Primary
Ortho-condensed systems · CPC title
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- What does patent US10899771B2 cover?
- The present invention is directed to processes for preparing beta 3 agonists of Formula (I) and Formula (II) and their intermediates. The beta 3 agonists are useful in the treatment of certain disorders, including overactive bladder, urinary incontinence, and urinary urgency.
- Who is the assignee on this patent?
- Merck Sharp & Dohme
- What technology area does this patent fall under?
- Primary CPC classification C07D487/04. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Jan 26 2021 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 6 related publications on this page (citations in our corpus or others sharing the same primary CPC).