Sample processing for microscopy
US-11112593-B2 · Sep 7, 2021 · US
US12174358B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-12174358-B2 |
| Application number | US-202217931414-A |
| Country | US |
| Kind code | B2 |
| Filing date | Sep 12, 2022 |
| Priority date | Mar 6, 2020 |
| Publication date | Dec 24, 2024 |
| Grant date | Dec 24, 2024 |
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A base assembly includes an imaging sensor having a sensor surface to receive a sample, and a platform connected to the base assembly. The base assembly includes (a) an aperture configured to receive a lid surface of a lid in a position to define an imaging space between the sensor surface and the lid surface and (b) a movement portion movable toward and away from the base assembly. The platform and the base assembly are configured to limit contact between the sample and the base assembly other than at the sensor surface.
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What is claimed is: 1. An apparatus comprising: a base assembly including an imaging sensor having a sensor surface to receive a sample; a first rigid platform segment surrounding the imaging sensor, the first rigid platform segment connected to the base assembly and comprising an aperture configured to receive a lid surface of a lid in a position to define an imaging space between the sensor surface and the lid surface; a second rigid platform segment surrounding the first rigid platform segment and spaced laterally apart from the first rigid platform segment, wherein the second rigid platform segment is configured to receive the lid resting on top of the second rigid platform segment, wherein the second rigid platform segment is movable toward and away from the base assembly, and wherein the second rigid platform segment is arranged such that movement of the second rigid platform segment toward and away from the base assembly results in the lid surface moving toward and away, respectively, from the sensor surface; and a pliant material coupled between the first rigid platform segment and the second rigid platform segment and arranged below the lid resting on the second rigid platform segment, wherein the pliant material has a flexibility that permits the movement of the second rigid platform segment toward and away from the base assembly. 2. The apparatus of claim 1 in which the first rigid platform segment has a fixed position with respect to the base assembly. 3. The apparatus of claim 1 in which the first rigid platform segment, the second rigid platform segment, and the pliant material are ring-shaped. 4. The apparatus of claim 1 , wherein the pliant material coupled between the first rigid platform segment and the second rigid platform segment is a first continuous portion of the pliant material, and wherein the apparatus further comprises a second continuous portion of the pliant material coupled to the second rigid platforms segment, wherein the first continuous portion of the pliant material and the second continuous portion of the pliant material are discontinuous with respect to one another. 5. The apparatus of claim 4 in which the second continuous portion of the pliant material is arranged circumferentially and concentrically around the aperture and the first continuous portion of the pliant material, and wherein the first continuous portion of the pliant material and the second continuous portion of the pliant material have two different radii. 6. The apparatus of claim 1 , comprising a movement mechanism coupled to the second rigid platform segment, wherein the movement mechanism is controllable to adjust a distance between the lid surface and the sensor surface. 7. The apparatus of claim 1 , comprising a motor configured to move the second rigid platform segment with respect to the base assembly. 8. The apparatus of claim 1 , comprising a peripheral surface configured to laterally bound a sample space situated between the peripheral surface, the sensor surface, and the lid surface. 9. The apparatus of claim 8 in which the sample space includes the imaging space. 10. The apparatus of claim 8 in which the sample space is configured to receive sample overflow from the imaging space. 11. The apparatus of claim 1 in which a top surface of the second rigid platform segment comprises one or more protrusions or depressions configured to receive the lid. 12. The apparatus of claim 11 in which the one or more protrusions or depressions are configured to mate with one or more corresponding protrusions or depressions formed by the lid. 13. The apparatus of claim 11 in which the one or more protrusions or depressions cause the lid to rest on the second rigid platform segment in a tilted orientation. 14. The apparatus of claim 1 comprising the lid having the lid surface. 15. The apparatus of claim 14 in which the lid surface comprises a protruding element that is configured to fit into the aperture. 16. The apparatus of claim 15 in which the protruding element comprises a trapezoidal prism. 17. The apparatus of claim 15 in which protruding element comprises a truncated cone. 18. The apparatus of claim 14 in which the lid is disposable. 19. The apparatus of claim 14 in which the lid and the second rigid platform segment are configured so that, as the lid is moved towards the base assembly while the sample is in the imaging space, the lid comes to rest on the sample and becomes unsupported by the second rigid platform segment. 20. The apparatus of claim 14 in which the lid and the second rigid platform segment are configured so that, as the lid is moved towards the base assembly, the lid surface becomes parallel to the sensor surface. 21. The apparatus of claim 14 , comprising one or more agents disposed on the lid surface. 22. The apparatus of claim 1 in which the pliant material is resistant to at least one cleaning or disinfection agent.
Microscope slides, e.g. mounting specimens on microscope slides · CPC title
Means for illuminating specimens · CPC title
specially adapted for specific applications, e.g. for endoscopes, ophthalmoscopes, attachments to conventional microscopes · CPC title
Base structure · CPC title
Details of detection or image processing, including general computer control · CPC title
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