Systems and methods for collision induced dissociation of ions in an ion trap

Patent metadata

Field	Value
Publication number	US-12154773-B2
Application number	US-202117144394-A
Country	US
Kind code	B2
Filing date	Jan 8, 2021
Priority date	Apr 6, 2016
Publication date	Nov 26, 2024
Grant date	Nov 26, 2024

Abstract

The invention generally relates to systems and methods for collision induced dissociation of ions in an ion trap. In certain aspects, the invention provides a system that includes a mass spectrometer having an ion trap, and a central processing unit (CPU). The CPU includes storage coupled to the CPU for storing instructions that when executed by the CPU cause the system to generate one or more signals, and apply the one or more signals to the ion trap in a manner that all ions within the ion trap are fragmented at a same Mathieu q value.

First claim

What is claimed is:

1. A mass spectrometry system comprising:
a mass spectrometer comprising an ion trap; and
a central processing unit (CPU), and storage coupled to the CPU for storing instructions that when executed by the CPU cause the system to:
generate a radio frequency (RF) signal comprising an amplitude; and
apply the RF signal to ions in the ion trap in a manner that after an injection and cooling period, the RF signal is increased and then a fixed frequency resonance excitation waveform is applied in presence of the RF signal for fragmenting the ions and the amplitude of the RF signal is then ramped in a reverse direction from high amplitude to low amplitude.

2. The system according to claim 1 , wherein the CPU further causes the system to: apply a second signal that is a fixed frequency resonance excitation waveform with the RF signal that is applied in the reverse direction.

3. The system according to claim 2 , wherein the fixed frequency resonance excitation waveform is a supplementary alternating current (AC) signal.

4. The system according to claim 3 , wherein an amplitude of the supplementary alternating current (AC) signal is varied as a function of time.

5. The system according to claim 4 , wherein the amplitude of the supplementary alternating current (AC) signal is ramped from a high amplitude to a low amplitude.

6. The system according to claim 2 , wherein the CPU further causes the system to adjust the RF signal and the supplementary AC signal applied to the ion trap in a manner that causes fragmented ions to be ejected from the ion trap.

Assignees

• Purdue Research Foundation

Inventors

• Cooks Robert Graham
• Snyder Dalton

Classifications

• H01J49/4295 Primary

  Storage methods · CPC title

• H01J49/427

  Ejection and selection methods · CPC title

• H01J49/0068

  by collision with a surface, e.g. surface induced dissociation · CPC title

• H01J49/0027

  Methods for using particle spectrometers · CPC title

• H01J49/0045

  characterised by the fragmentation or other specific reaction · CPC title