Hemostatic composition and hemostatic method using hemostatic composition

Patent metadata

Field	Value
Publication number	US-12138291-B2
Application number	US-202217697459-A
Country	US
Kind code	B2
Filing date	Mar 17, 2022
Priority date	Dec 18, 2015
Publication date	Nov 12, 2024
Grant date	Nov 12, 2024

Abstract

[Problem to be Solved]
It is intended to provide a composition for hemostasis which can be uniformly applied to a bleeding site and exerts a high hemostatic effect.
[Solution]
The present invention provides a composition to be applied as a spray to a subject, the spray being used for hemostasis, and the composition comprising a self-assembling peptide, wherein the self-assembling peptide self-assembles and thereby gels when the composition is applied to a bleeding site of the subject, and the self-assembling peptide is contained in the composition at a concentration at which the composition has an improved hemostatic ability as compared with that when directly applied.

First claim

The invention claimed is:

1. A spray apparatus loaded with a composition comprising the self-assembling peptide IEIK13 (SEQ ID NO:2) in solution,
wherein the concentration of IEIK13 (SEQ ID NO:2) in solution is 1.5% to 3% by weight;
wherein a pressure applied to the peptide solution by the spray apparatus is in the range between 0.5 kgf/cm 2 to 1.5 kgf/cm 2 ; and
wherein the sprayed self-assembling peptide self-assembles after being sprayed onto a bleeding site of a subject, thereby forming a gel and preventing further bleeding from the site.

2. The spray apparatus of claim 1 , wherein the bleeding site of the subject is a non-surgically formed wound site or a surgically formed incision site or excision site.

3. The spray apparatus of claim 1 , wherein the subject is human.

4. The spray apparatus of claim 1 , wherein the apparatus comprises a spray gun.

Assignees

• 3 D Matrix Ltd

Inventors

• Nagano Keiji
• Kobayashi Satoru

Classifications

• A61P17/02

  for treating wounds, ulcers, burns, scars, keloids, or the like · CPC title

• A61P7/04

  Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents · CPC title

• A61K38/08

  Peptides having 5 to 11 amino acids {(A61K38/043 - A61K38/046 take precedence)} · CPC title

• A61L2400/04

  Materials for stopping bleeding · CPC title

• A61K9/7015

  Drug-containing film-forming compositions, e.g. spray-on · CPC title