Drug delivery device

Patent metadata

Field	Value
Publication number	US-12115341-B2
Application number	US-201314443847-A
Country	US
Kind code	B2
Filing date	Nov 20, 2013
Priority date	Nov 21, 2012
Publication date	Oct 15, 2024
Grant date	Oct 15, 2024

Abstract

A drug delivery device includes a blunt cannula and a reservoir. The blunt cannula has a cylindrical wall that defines an axial passage between a first end and a second end of the blunt cannula. The wall has at least a first tapered region at the first end to define an opening in fluid communication with the axial passage and adapted at the first end to resist interruption of fluid flow through the axial passage and out of the first end of the blunt cannula. The reservoir is connected to the second end of the blunt cannula.

First claim

We claim:

1. A wearable drug delivery device comprising:
a housing having an opening;
a blunt cannula moveable relative to the housing and having a cylindrical wall that defines an axial passage between a first end and a second end of the blunt cannula, the wall having at least a first tapered region at the first end to define an opening in fluid communication with the axial passage, and at least one side port formed in the wall at the first end of the blunt cannula to resist interruption of fluid flow through the axial passage and out of the first end of the blunt cannula, wherein no side ports are formed in the wall of the blunt cannula at the second end of the blunt cannula;
a reservoir for storing a drug prior to operation of the wearable drug delivery device and configured to be in fluid communication with the second end of the blunt cannula at least during drug delivery;
a needle or connector configured to connect the blunt cannula in fluid communication with the reservoir;
a hub disposed at or coupled with the second end of the blunt cannula, the hub at least partially surrounding at least a portion of the needle or connector; and
wherein the blunt cannula is initially retracted within the housing and subsequently the first end of the blunt cannula is deployed through the opening in the housing in an operative state, wherein the second end of the blunt cannula is disposed within the housing in the operative state.

2. The drug delivery device according to claim 1 , the at least one side port being disposed within the first tapered region at the first end of the blunt cannula.

3. The drug delivery device according to claim 2 , wherein the at least one side port comprises a pair of side ports.

4. The drug delivery device according to claim 3 , wherein the pair of side ports are aligned with each other across the axial passage.

5. The drug delivery device according to claim 1 , wherein the at least one side port comprises a circular opening formed in the wall to permit flow transverse to the axial passage.

6. The drug delivery device according to claim 1 , wherein the at least one side port comprises an elongated slit formed in the wall to permit flow transverse to the axial passage.

7. The drug delivery device according to claim 1 , wherein the at least one side port comprises an elongated slot formed in the wall to permit flow transverse to the axial passage.

8. The drug delivery device according to claim 1 , wherein the at least one side port is formed in the first end of the blunt cannula distal from the first tapered region.

9. The drug delivery device according to claim 1 , wherein the first tapered region comprises at least one bevel.

10. The drug delivery device according to claim 9 , wherein the first tapered region comprises only one bevel.

11. The drug delivery device according to claim 9 , wherein the first tapered region comprises two bevels intersecting each other.

12. The drug delivery device according to claim 9 , wherein the first tapered region comprises two negative or inverted bevels intersecting each other.

13. The drug delivery device according to claim 1 , wherein the first end includes a pattern of openings disposed about the opening in the first tapered region.

14. The drug delivery device according to claim 13 , wherein the pattern of openings comprises a pattern of recesses into the wall.

15. The drug delivery device according to claim 1 , wherein the blunt cannula has at least one external recessed region recessed toward the axial passage relative to adjoining surface regions.

16. The drug delivery device according to claim 15 , wherein the at least one external recessed region is defined by a pattern of ribs.

17. The drug delivery device according to claim 15 , wherein the at least one external recessed surface region is defined by a pattern of grooves.

18. The drug delivery device according to claim 1 , further comprising a vibration generator coupled to the blunt cannula, the generator being configured to be actuated to resist interruption of fluid flow through the axial passage and out of the first end of the blunt cannula.

19. The drug delivery device according to claim 1 , further comprising:
a barrel and a plunger disposed within the barrel to define the reservoir; and
the housing having an outer surface attachable to the patient, wherein the opening in the housing is formed in the outer surface of the housing.

20. The drug delivery device according to claim 1 , wherein the opening of the housing has a diameter that is less than twice a diameter of the cannula.

21. The wearable drug delivery device of claim 1 , comprising an introducer needle disposed in the blunt cannula and adapted to protrude outwardly from the opening in the first end of the blunt cannula for introducing the blunt cannula into skin of the patient and subsequently retract into the opening in the first end of the blunt cannula prior to drug delivery.

22. The wearable drug delivery device of claim 1 , comprising a drive operatively coupled to the reservoir to force fluid from the reservoir through the blunt cannula.

23. The wearable drug delivery device of claim 22 , wherein the drive is automated.

24. The drug delivery device according to claim 1 , wherein the hub at least partially surrounds an axis parallel to the axial passage of the blunt cannula.

25. The drug delivery device according to claim 1 , comprising a volume of a granulocyte colony-stimulating factor (G-CSF) disposed in the reservoir.

26. The drug delivery device according to claim 25 , wherein the G-CSF comprises a pegylated G-CSF.

27. A wearable drug delivery device comprising:
a housing having an outer surface attachable to a patient, an opening being formed in the outer surface of the housing;
a rigid needle moveable relative to the housing and having a cylindrical wall that defines an axial passage between a first end and a second end of the rigid needle, the wall having an opening at the first end in fluid communication with the axial passage and adapted at the first end to resist interruption of fluid flow through the axial passage and out of the first end of the rigid needle; and
a reservoir configured to be in fluid communication with the second end of the rigid needle at least during drug delivery,
wherein the first end includes a pattern of openings disposed about the opening in the first end, and at least one external recessed region recessed toward the axial passage relative to adjoining surface regions, the at least one external recessed region being distal from the pattern of openings toward the second end of the rigid needle, and
wherein the rigid needle is initially retracted within the housing and subsequently deployed through the opening in the housing to define an operative state.

28. The drug delivery device according to claim 27 , wherein the pattern of openings comprises a pattern of recesses into the wall.

29. The drug delivery device according to claim 27 , wherein the at least one external recessed region is defined by a pattern of ribs.

30. The drug delivery device according to claim 27 , wherein the at least one external recessed surface region is defined by a pattern of grooves.

31. The drug delivery device according to claim 27 , further comprising a vibration generator coupled to the rigid

Assignees

• Amgen Inc

Inventors

• Ring Lawrence
• Mehta Dhairya
• Toy Stephanie
• Tamtoro Ferry
• Cairns Alexander Stuart
• Gibson Scott R

Classifications

• A61M5/14216

  Reciprocating piston type · CPC title

• A61K9/0019

  Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner (non-active ingredients are additionally classified in A61K47/00) · CPC title

• A61M2005/3022

  Worn on the body, e.g. as patches (pressure infusion of the skin patch type A61M5/14248) · CPC title

• A61M5/3134

  characterised by constructional features of the distal end, i.e. end closest to the tip of the needle cannula · CPC title

• A61M5/14

  Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor · CPC title