Apparatus for fluid line management in a bioprocessing system

Patent metadata

Field	Value
Publication number	US-12077743-B2
Application number	US-201916968333-A
Country	US
Kind code	B2
Filing date	Feb 8, 2019
Priority date	Feb 9, 2018
Publication date	Sep 3, 2024
Grant date	Sep 3, 2024

Abstract

In an embodiment, a tubing module for a bioprocessing system includes a first tubing holder block configured to receive at least one pump tube and hold the at least one pump tube in position for selective engagement with a peristaltic pump, a second tubing holder block configured to receive a plurality of pinch valve tubes and hold each pinch valve tube of the plurality of pinch valve tubes in position for selective engagement with a respective actuator of a pinch valve array, and wherein the first tubing holder block and the second tubing holder block are interconnected.

First claim

What is claimed is:

1. A system for bioprocessing, comprising:
a tray having a plurality of sidewalls and a bottom surface defining an interior compartment, and a generally open top, the tray being configured to receive a bioreactor vessel;
a pump assembly positioned adjacent to the rear sidewall of the tray;
a pinch valve array positioned adjacent to the rear sidewall of the tray; and
a tubing module positioned at a rear of the tray, the tubing module including:
a first tubing holder block configured to receive at least one pump tube and hold the at least one pump tube in position for selective engagement with the pump assembly; and
a second tubing holder block configured to receive a plurality of pinch valve tubes and hold each pinch valve tube of the plurality of pinch valve tubes in position for selective engagement with a respective actuator of the pinch valve array.

2. The system of claim 1 , wherein:
the tubing module is integral with the tray.

3. The system of claim 1 , wherein:
the tubing module is removably received by an opening formed in a rear wall of the tray.

4. The system of claim 1 , further comprising:
a temperature controlled processing chamber having a plurality of sidewalls, a bottom surface, and a generally open top, wherein the tray is receivable by the processing chamber;
wherein the processing chamber includes a shoe that extends upwardly from the processing chamber and is received through a first clearance opening in the tubing module; and
wherein the at least one pump tube is received intermediate the pump assembly and the shoe.

5. The system of claim 4 , wherein:
the processing chamber includes an anvil that extends upwardly from the processing chamber and is received through a second clearance opening in the tubing module; and
wherein the plurality of pinch valve tubes are received intermediate the pinch valve array and the anvil.

6. The system of claim 5 , wherein:
the second tubing holder block of the tubing module includes a back plate having a plurality of apertures corresponding to the plurality of pinch valve tubes;
wherein the plurality of pinch valve tubes are positioned adjacent to the back plate wall when the plurality of tubes are received by the second tubing holder block.

7. The system of claim 6 , wherein:
the plurality of apertures includes a first column of apertures and a second column of apertures;
wherein the apertures in the first column of apertures are offset in a vertical direction with respect to the apertures on the second column of apertures so that the apertures in the first column of apertures are not in horizontal alignment with the apertures in the second column of apertures.

8. The system of claim 7 , wherein:
each aperture of the plurality of apertures is arranged so as to be aligned with an actuator of the pinch valve array so as to allow engagement of the actuator with the plurality of pinch valve tubes through the plurality of apertures.

9. The system of claim 1 , wherein:
the tubing module includes at least one of a hollow fiber filter and/or a tangential flow filtration device coupled to the tubing module.

10. The system of claim 1 , wherein:
the tubing module includes at least one vessel tubing clip for retaining one of a drain line and a feed line connected to the bioreactor vessel.

11. The system of claim 1 , wherein:
the first tubing holder block is configured to hold the at least one pump tube in a substantially linear orientation.

12. The system of claim 1 , wherein:
the tubing module includes a media line tubing holder having a plurality of slots configured to receive and retain media tubing.

13. The system of claim 1 , wherein:
the tubing module is one of 3D printed or injection molded; and
the tray is one of thermoformed or injection molded.

14. A system for bioprocessing, comprising:
a tray having a plurality of sidewalls and a bottom surface defining an interior compartment, and a generally open top, the tray being configured to receive a bioreactor vessel;
a pump assembly positioned adjacent to the rear sidewall of the tray;
a pinch valve array positioned adjacent to the rear sidewall of the tray; and
a tubing module positioned at a rear of the tray, the tubing module including:
a first tubing holder block configured to receive at least one pump tube and hold the at least one pump tube in position for selective engagement with the pump assembly; and
a second tubing holder block configured to receive a plurality of pinch valve tubes and hold each pinch valve tube of the plurality of pinch valve tubes in position for selective engagement with a respective actuator of the pinch valve array;
wherein the tubing module forms the rear sidewall of the tray and defines a boundary of the interior compartment.

Assignees

• Global Life Sciences Solutions Usa Llc

Inventors

• Griffin Weston Blaine
• Corwin Alex D
• Zhang Xiaohua
• Smith Reginald Donovan
• Liu Zhen
• Zhang Chengkun
• Keskar Vandana
• Davis Brian Michael
• Shaikh Kashan

Classifications

• C12M25/06

  Plates; Walls; Drawers; Multilayer plates · CPC title

• C12M23/08

  Flask, bottle or test tube · CPC title

• C12M25/02

  Membranes; Filters (filters or filtration in general B01D24/00-B01D41/00) · CPC title

• C12M33/00

  Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus (chemical or physical laboratory apparatus in general B01L, devices for taking cell samples A61B10/0045, withdrawing or distributing predetermined quantities of fluid B01L99/00) · CPC title

• C12M29/26

  Conditioning fluids entering or exiting the reaction vessel · CPC title