Stapled H2 pyrin peptides

Patent metadata

Field	Value
Publication number	US-12077608-B2
Application number	US-201917268818-A
Country	US
Kind code	B2
Filing date	Aug 15, 2019
Priority date	Aug 16, 2018
Publication date	Sep 3, 2024
Grant date	Sep 3, 2024

Abstract

Peptides useful as inflammasome inhibitors are disclosed and can comprise an H2 helix of a pyrin domain, wherein at least two non-consecutive amino acids of the H2 helix are covalently linked. Methods of treating a subject with a disease comprising administering to the subject the disclosed peptides are also disclosed. Further, disclosed herein are methods of inhibiting binding between a first polypeptide comprising a pyrin domain and a second polypeptide comprising a pyrin domain, the method comprising contacting either the first polypeptide or the second polypeptide with the disclosed peptides.

First claim

What is claimed is:

1. A peptide comprising a H2 helix of a pyrin domain; wherein the peptide consists of only one pyrin domain helical structure; wherein the peptide is 15 amino acids or less; and wherein at least two non-consecutive amino acids of the H2 helix are covalently linked.

2. The peptide of claim 1 , wherein the peptide comprises fSAH-POP1-1 (SEQ ID NO: 1), fSAH-POP1-3 (SEQ ID NO: 3), fSAH-POP1-4 (SEQ ID NO: 4), fSAH-POP1-5 (SEQ ID NO: 5), fSAH-POP1-6 (SEQ ID NO: 6), fSAH-POP1-7 (SEQ ID NO: 7), fSAH-POP1-8 (SEQ ID NO: 8), fSAH-POP1-9 (SEQ ID NO: 9), fSAH-POP1-10 (SEQ ID NO: 10), fSAH-POP1-11 (SEQ ID NO: 11), fSAH-POP1-12 (SEQ ID NO: 12), fSAH-POP1-13 (SEQ ID NO: 13), fSAH-POP1-14 (SEQ ID NO: 14), fSAH-POP1-15 (SEQ ID NO: 15), fSAH-POP1-16 (SEQ ID NO: 16), fSAH-POP1-17 (SEQ ID NO: 17), fSAH-POP1-18 (SEQ ID NO: 18), fSAH-POP1-19 (SEQ ID NO: 19), fSAH-POP1-20 (SEQ ID NO: 20), fSAH-POP1-21 (SEQ ID NO: 21), fSAH-POP1-22 (SEQ ID NO: 22), fSAH-POP1-23 (SEQ ID NO: 23), fSAH-POP1-24 (SEQ ID NO: 24), fSAH-POP1-25 (SEQ ID NO: 25), fSAH-POP1-26 (SEQ ID NO: 26), fSAH-POP1-27 (SEQ ID NO: 27), fSAH-POP1-28 (SEQ ID NO: 28), fSAH-POP1-29 (SEQ ID NO: 29), fSAH-POP1-30 (SEQ ID NO: 30), fSAH-POP1-31 (SEQ ID NO: 31), SAH-POP1-1 (SEQ ID NO: 32), SAH-POP1-2 (SEQ ID NO: 33), SAH-POP1-3 (SEQ ID NO: 34), SAH-POP1-4 (SEQ ID NO: 35), SAH-POP1-5 (SEQ ID NO: 36), SAH-POP1-6 (SEQ ID NO: 37), SAH-POP1-7 (SEQ ID NO: 38), SAH-POP1-8 (SEQ ID NO: 39), SAH-POP1-17 (SEQ ID NO: 44), and/or SAH-POP1-18 (SEQ ID NO: 45).

Assignees

• H Lee Moffitt Cancer Ct & Res

Inventors

• List Alan
• Ji Haitao

Classifications

• A61K38/00

  Medicinal preparations containing peptides (peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00) · CPC title

• C07K14/47

  from mammals · CPC title

• A61P35/02

  specific for leukemia · CPC title

• C07K7/08 Primary

  having 12 to 20 amino acids (gastrins C07K14/595; somatostatins C07K14/655; melanotropins C07K14/68) · CPC title

• A61P29/00 Primary

  Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title