3, 7-diamino-10H-phenothiazine salts and their use
US-11344558-B2 · May 31, 2022 · US
US12064439B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-12064439-B2 |
| Application number | US-202117499498-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 12, 2021 |
| Priority date | Feb 11, 2011 |
| Publication date | Aug 20, 2024 |
| Grant date | Aug 20, 2024 |
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Disclosed are compounds of general formula (I):and pharmaceutically acceptable salts thereof, formulations, methods and uses in, for example, the treatment of disease.
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The invention claimed is: 1. A dosage unit comprising 20 to 300 mg of a compound of the following formula: or comprising 20 to 300 mg of a free base equivalent of said compound, and further comprising a pharmaceutically acceptable carrier, diluent, or excipient. 2. The dosage unit according to claim 1 , which is a tablet comprising 20 to 300 mg of the compound. 3. The dosage unit according to claim 1 , which is a capsule comprising 20 to 300 mg of the compound. 4. The dosage unit according to claim 1 , which comprises 30 to 200 mg of the compound. 5. The dosage unit according to claim 1 , which comprises about 30 mg of the compound. 6. The dosage unit according to claim 1 , in which less than 12% of said compound is converted to methylthionium: over 2 years when stored at 25° C. at a relative humidity of 60%. 7. The dosage unit according to claim 1 , which comprises about 60 mg of the compound. 8. The dosage unit according to claim 1 , which comprises about 100 mg of the compound. 9. The dosage unit according to claim 1 , which comprises about 150 mg of the compound. 10. The dosage unit according to claim 1 , which comprises about 200 mg of the compound. 11. The dosage unit according to claim 1 , which is a tablet comprising 20 to 300 mg of the free base equivalent of the compound. 12. The dosage unit according to claim 1 , which is a capsule comprising 20 to 300 mg of the free base equivalent of the compound. 13. The dosage unit according to claim 1 , which comprises 30 to 200 mg of the free base equivalent of the compound. 14. The dosage unit according to claim 1 , which comprises about 30 mg of the free base equivalent of the compound. 15. The dosage unit according to claim 1 , which comprises about 60 mg of the free base equivalent of the compound. 16. The dosage unit according to claim 1 , which comprises about 100 mg of the free base equivalent of the compound. 17. The dosage unit according to claim 1 , which comprises about 150 mg of the free base equivalent of the compound. 18. The dosage unit according to claim 1 , which comprises about 200 mg of the free base equivalent of the compound.
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