Systems and methods for probe tip heating

Patent metadata

Field	Value
Publication number	US-12050232-B2
Application number	US-202117567041-A
Country	US
Kind code	B2
Filing date	Dec 31, 2021
Priority date	Dec 31, 2021
Publication date	Jul 30, 2024
Grant date	Jul 30, 2024

Abstract

Systems and methods for probe tip heating are disclosed. An exemplary system for probe tip heating can include an enclosure enclosing a probe tip, a heating device, and a fan. The probe tip can be configured to access an internal volume of a stoppered container and to aspirate or dispense a material from or to the internal volume of the stoppered container. The heating device can be configured to heat air circulating within the enclosure. The fan can be positioned to circulate air within the enclosure to heat the tip of the probe.

First claim

What is claimed is:

1. A system for heating a probe, comprising:
an enclosure containing, in part, a heating loop and a probe loop, the enclosure enclosing:
a tip of a probe, the tip of the probe configured to access an internal volume of a stoppered container and to aspirate or dispense a material from or to the internal volume of the stoppered container;
a heating device within the heating loop; and
a fan positioned to circulate air:
within the heating loop contained in the enclosure to heat the air; and
within the probe loop contained in the enclosure to heat the tip of the probe.

2. The system of claim 1 , wherein:
the heating loop contains a choke to restrict airflow through the heating loop.

3. The system of claim 1 , wherein:
the enclosure encloses:
a high-pressure location;
a low-pressure location, the fan disposed between the high-pressure location and the low-pressure location; and
an internal sleeve included in the probe loop, the internal sleeve including an inlet connecting the high-pressure location to the internal sleeve.

4. The system of claim 3 , wherein:
the inlet comprises at least two slots, each of the at least two slots parallel to the probe tip.

5. The system of claim 3 , wherein:
the internal sleeve includes an outlet slot, the outlet slot parallel to the probe tip.

6. The system of claim 1 , wherein:
the system includes at least one of:
a temperature sensor configured to measure an air temperature in the enclosure; or
a temperature sensor configured to measure a temperature of the heating device.

7. The system of claim 1 , wherein:
the system includes a temperature sensor configured to directly measure an air temperature in either in a high-pressure location of the enclosure or a low-pressure location of the enclosure.

8. The system of claim 1 , wherein:
the system includes a temperature sensor configured to indirectly measure an air temperature or a temperature of the heating device.

9. The system of claim 1 wherein:
the probe tip is configured to aspirate reagents and the enclosure further encloses a second tip of a second probe configured to aspirate samples.

10. A method for heating a probe tip of a probe for aspirating and dispensing fluids, comprising:
circulating air, using a fan contained in an enclosure, within a heating loop contained in the enclosure to contact a heating device and within a probe loop contained in the enclosure to contact the probe tip of a probe positioned within the enclosure, the probe tip of the probe configured to access an internal volume of a stoppered container and to aspirate or dispense a material from or to the internal volume of the stoppered container.

11. The method of claim 10 , wherein:
the enclosure contains a high-pressure reservoir, a low-pressure reservoir, and an internal sleeve;
circulating the air within the enclosure comprises circulating a first fraction of the air from the high-pressure reservoir, though the internal sleeve, and into the low-pressure reservoir; and
circulating a second fraction of the air from the high-pressure reservoir, past the heating device, and into the low-pressure reservoir.

12. The method of claim 11 , the method further comprising:
adjusting a temperature of the heating device based on at least one of:
an air temperature measurement for the high-pressure reservoir; or
a temperature of the heating device.

13. The method of claim 11 , wherein:
circulating the first fraction of the air though the internal sleeve comprises circulating the first fraction of the air though input slots configured to direct the first fraction of the air onto the probe tip.

14. A method for transferring fluid using a probe tip, comprising:
aspirating fluid into a reservoir of a probe through a probe tip that accesses an internal volume of a stoppered container, the probe positioned within an enclosure containing a probe loop and a heating loop;
translating the probe to a withdrawn position within the enclosure and circulating air within the probe loop contained in the enclosure, using a fan contained in the enclosure, to contact the probe tip to heat the probe tip; and
translating the probe to a dispense position within the enclosure and dispensing a portion of the fluid from the reservoir.

15. The method of claim 14 , wherein:
the method further includes circulating the air through the heating loop contained in the enclosure to contact a heating device using the fan.

16. The method of claim 15 , wherein:
a fraction of the air circulating through the heating loop increases when the probe is translated to the dispense position.

17. The method of claim 15 , wherein:
the method further comprises controlling at least one of a temperature of the heating device or a speed of the fan to heat the probe tip to a temperature within a specified temperature range prior to dispensing the portion of the fluid from the reservoir or prior to aspirating the fluid from a container.

18. The method of claim 15 , wherein:
the method further comprises controlling at least one of a temperature of the heating device or a speed of the fan based on at least one of:
a volume of the fluid aspirated;
a velocity of aspiration; or
a time between aspirating the fluid and dispensing the portion of the fluid.

Assignees

• Instr Laboratory Co

Inventors

• Christoff Chris
• Shreve Joshua A
• Hebert Reed
• Newton Benjamin

Classifications

• B01L7/525

  with physical movement of samples between temperature zones · CPC title

• G01N2035/00425

  Heating or cooling means associated with pipettes or the like, e.g. for supplying sample/reagent at given temperature · CPC title

• G01N35/1002

  Reagent dispensers · CPC title

• G01N35/10

  Devices for transferring samples {or any liquids} to, in, or from, the analysis apparatus, e.g. suction devices, injection devices {(G01N35/0099 takes precedence)} · CPC title

• B01L2200/147

  Employing temperature sensors · CPC title