Method for heating a volume of liquid in a heated pipetting needle

Patent metadata

Field	Value
Publication number	US-9821305-B2
Application number	US-201313753858-A
Country	US
Kind code	B2
Filing date	Jan 30, 2013
Priority date	Jan 31, 2012
Publication date	Nov 21, 2017
Grant date	Nov 21, 2017

Abstract

The invention relates to a pipetting device for automatic analysis instruments and a method for heating a volume of liquid in a heated pipetting needle.

First claim

The invention claimed is:

1. A device for pipetting a volume of liquid, wherein the device comprises the following components:
a) a heatable pipetting needle comprising (i) a cylindrical needle body and a conical needle tip at a downstream end of the cylindrical needle body, (ii) a closed-loop controllable heating device comprising a heating wire wound around the needle along a longitudinal heated section extending substantially the length of the cylindrical needle body, the conical needle tip being free of the heating device, and (iii) a sensor region located longitudinally within the longitudinal heated section such that the longitudinal heated section extends beyond the sensor region both upstream and downstream of the sensor region, the sensor region having a temperature sensor mounted therein;
b) a closed loop controller for setting a constant intended temperature of the pipetting needle; and
c) a data-processing unit configured for:
setting a volume of liquid to be drawn into the pipetting needle; and
setting a volume of air to be drawn into the pipetting needle after a set volume of liquid is drawn into the pipetting needle, wherein the volume of air is set based on the set volume of liquid such that a previously drawn-in set volume of liquid will extend along at least a portion of the longitudinal heated section for a distance extending both upstream and downstream of the sensor region in which the temperature sensor is mounted.

2. The device according to claim 1 , wherein the data-processing unit is configured to set a volume of air to be drawn into the pipetting needle after a set volume of liquid is drawn into the pipetting needle, such that a set volume of liquid will pass completely through the region of the heated pipetting needle having the temperature sensor mounted therein.

3. An analysis instrument for automatically analyzing samples, comprising:
a device for pipetting a volume of liquid, the device comprising:
a) a heatable pipetting needle comprising (i) a cylindrical needle body and a conical needle tip at a downstream end of the cylindrical needle body, (ii) a closed-loop controllable heating device comprising a heating wire wound around the needle along a longitudinal heated section extending substantially the length of the cylindrical needle body, the conical needle tip being free of the heating device, and (iii) a sensor region located longitudinally within the longitudinal heated section such that the longitudinal heated section extends beyond the sensor region both upstream and downstream of the sensor region, the sensor region having a temperature sensor mounted therein;

b) a closed loop controller for setting a constant intended temperature of the pipetting needle;
c) a data-processing unit configured for:
setting a volume of liquid to be drawn into the pipetting needle; and
setting a volume of air to be drawn into the pipetting needle after a set volume of liquid is drawn into the pipetting needle, wherein the volume of air is set based on the set volume of liquid such that a previously drawn-in set volume of liquid will extend along at least a portion of the longitudinal heated section for a distance extending both upstream and downstream of the sensor region in which the temperature sensor is mounted; and

a reaction container configured to receive the volume of liquid from the heatable pipetting needle, wherein the liquid is reacted with at least one sample or reagent to form a reaction product; and
an analysis unit configured to analyze the reaction product.

4. The analysis instrument as claimed in claim 3 , wherein the data-processing unit for setting a volume of liquid to be drawn in, sets the volume of liquid to be drawn in on the basis of information which defines a specific test method.

5. The analysis instrument as claimed in claim 3 , wherein the data-processing unit for setting a volume of air to be drawn in, sets the volume of air to be drawn in on the basis of information which defines a specific test method.

Assignees

• Siemens Healthcare Diagnostics Products Gmbh

Inventors

• Michels Thorsten
• Selvi Ayhan
• Wiedekind-Klein Alexander

Classifications

• G01N35/10

  Devices for transferring samples {or any liquids} to, in, or from, the analysis apparatus, e.g. suction devices, injection devices {(G01N35/0099 takes precedence)} · CPC title

• B01L7/00

  Heating or cooling apparatus (autoclaves B01J3/04); Heat insulating devices · CPC title

• B01L2300/0838

  Capillaries · CPC title

• B01L2300/18

  Means for temperature control · CPC title

• B01L2300/1888

  Pipettes or dispensers with temperature control · CPC title