Compositions for ophthalmologic devices

Patent metadata

Field	Value
Publication number	US-12049606-B2
Application number	US-202117546434-A
Country	US
Kind code	B2
Filing date	Dec 9, 2021
Priority date	Jan 12, 2021
Publication date	Jul 30, 2024
Grant date	Jul 30, 2024

Abstract

The present invention relates to borate and phosphate containing compositions, especially eye care compositions, achieving physiologically compatible pH and tonicity as well as good bacteriostatic properties. Methods of using the compositions of the present invention are also disclosed.

First claim

What is claimed is:

1. A composition, comprising:
a. from about 0.1% w/v to less than or equal to about 0.6% w/v of a borate compound;
b. from about 0.3% w/v to about 0.9% w/v of a phosphate compound; and
c. ophthalmologically acceptable carrier
wherein the ratio of the phosphate compound to the borate compound is at least about 1.5:1 on a weight basis;
and wherein the composition is free of preservatives.

2. The composition of claim 1 wherein the composition comprises from about 0.2% w/v to less than or equal to 0.5% w/v of a borate compound.

3. The composition of claim 2 wherein the composition comprises from about 0.25% w/v to less than or equal to 0.45% w/v of a borate compound.

4. The composition of claim 3 wherein the composition comprises from about 0.25% w/v to less than or equal to 0.4% w/v of a borate compound.

5. The composition of claim 1 wherein the composition comprises from about 0.4% w/v to about 0.85% w/v of a phosphate compound.

6. The composition of claim 5 wherein the composition comprises from about 0.5% w/v to about 0.8% w/v of a phosphate compound.

7. The composition of claim 1 wherein the ratio of the phosphate compound to the borate compound is at least about 2.5:1 on a weight basis.

8. The composition of claim 1 wherein the ratio of the phosphate compound to the boric acid compound is from about 1.5:1 to about 3:1 on a weight basis.

9. The composition of claim 1 wherein the ratio of the phosphate compound to the boric acid compound is from about 2:1 to about 3:1 on a weight basis.

10. The composition of claim 1 further comprising a demulcent polymer.

11. The composition of claim 10 , wherein the demulcent polymer is selected from block copolymers of polyethyleneoxide (PEO) and polypropyleneoxide (PPO), polyvinyl alcohol, polyvinyl pyrrolidone, polyacrylic acid, polyethers, hyaluronic acid and hyaluronic acid derivatives, chitosan, polysorbates, dextrans, cellulosic derivatives, acyclic polyamides, salts thereof and mixture thereof.

12. The composition of claim 1 further comprising additional components selected from cleaning agents, wetting agents, nutrient agents, therapeutic agent, sequestering agents, viscosity builders, contact lens conditioning agents, antioxidants, and the like and mixtures thereof.

Assignees

• Johnson & Johnson Vision Care

Inventors

• Neely Frank
• Riederer Donald E
• Wegrzyn Jeffrey

Classifications

• C11D3/43

  Solvents · CPC title

• C11D3/06

  Phosphates, including polyphosphates · CPC title

• C11D3/046

  Salts · CPC title

• C11D3/042

  Acids · CPC title

• A61L2300/404

  Biocides, antimicrobial agents, antiseptic agents · CPC title