Medical devices and implements with liquid-impregnated surfaces

Patent metadata

Field	Value
Publication number	US-12005161-B2
Application number	US-202318317913-A
Country	US
Kind code	B2
Filing date	May 15, 2023
Priority date	May 24, 2012
Publication date	Jun 11, 2024
Grant date	Jun 11, 2024

Abstract

Described herein are medical devices and medical implements with high lubricity to flesh (or biological fluid) and/or inhibited nucleation on its surface. The device has a surface comprising an impregnating liquid and a plurality of micro-scale and/or nano-scale solid features spaced sufficiently close to stably contain the impregnating liquid therebetween. The impregnating liquid fills spaces between said solid features, the surface stably contains the impregnating liquid between the solid features, and the impregnating liquid is substantially held in place between the plurality of solid features regardless of orientation of the surface.

First claim

What is claimed is:

1. A medical device or medical implement with high lubricity to flesh or biological fluid and/or inhibited nucleation on its surface, the device or implement comprising:
a surface comprising an impregnating liquid and a plurality of micro-scale and/or nano-scale solid features spaced sufficiently close to stably contain the impregnating liquid therebetween,
wherein said impregnating liquid fills spaces between said solid features,
wherein said surface stably contains said impregnating liquid between said solid features,
wherein at least a portion of the micro-scale and/or nano-scale solid features are non-submerged by the impregnating liquid when the surface is in contact with the flesh or the biological fluid,
wherein 0<ϕ<0.3, where ϕ is a surface area fraction of the surface non-submerged by said impregnating liquid,
wherein said surface is a textured surface and said solid features are engineered protrusions or engineered particles of said textured surface, and
wherein the impregnating liquid comprises a medication or drug.

2. A medical device as in claim 1 , wherein the drug comprises an antiseptic and/or an antibacterial.

3. A medical device as in claim 1 , wherein 0<ϕ≤0.25, where ϕ is a representative fraction of the projected surface area of the liquid-impregnated surface corresponding to non-submerged solid at equilibrium.

4. The medical device or medical implement of claim 1 , wherein the solid features comprise particles having an average dimension in a range of 1 micron to 50 microns.

5. The medical device or medical implement of claim 1 , wherein the particles are arranged with average spacing of about 1 micron to about 30 microns between adjacent particles or clusters of particles.

6. The medical device or medical implement of claim 1 , wherein the particles are spray-deposited.

7. The medical device or medical implement of claim 1 , wherein the impregnating liquid comprises at least one member selected from the group consisting of ethyl oleate, an ester, a fatty acid, a fatty acid derivative, a vegetable oil, a terpene, phenyl isothiocyanate, bromobenzene, iodobenzene, o-bromotoluene, alpha-chloronaphthalene, alpha-bromonaphthalene, acetylene tetrabromide, 1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl) imide (BMIm), tribromohydrin (1,2,3-tribromopropane), ethylene dibromide, carbon disulfide, bromoform, methylene iodide (diiodomethane), stanolax, Squibb's liquid petrolatum, p-bromotoluene, monobromobenzene, perchloroethylene, carbon disulfide, phenyl mustard oil, monoiodobenzene, alpha-monochloro-naphthalene, acetylene tetrabromide, aniline, butyl alcohol, isoamyl alcohol, n-heptyl alcohol, cresol, oleic acid, linoleic acid, and amyl phthalate.

8. The medical device or medical implement of claim 1 , wherein the solid features comprise one or more members selected from the group consisting of wax, carnauba wax, beeswax, candelilla wax, zein (from corn), dextrin, cellulose ether, hydroxyethyl cellulose, hydroxypropyl cellulose (HPC), hydroxyethyl methyl cellulose, hydroxypropyl methyl cellulose (HPMC), ethyl hydroxyethyl cellulose, insoluble fiber, purified wood cellulose, micro-crystalline cellulose, kaolinite (clay mineral), Japan wax, pulp (e.g., spongy part of plant stems), ferric oxide, iron oxide, sodium formate, sodium oleate, sodium palmitate, sodium sulfate, a metal, a polymer, a ceramic solid, a fluorinated solid, an intermetallic solid, and a composite solid PDMS, cyclic olefin polymer, polypropylene, PVC, PET, HDPE, polyimide, PMMA, glass, Perspex, Plexiglass, and Polymacon.

9. The medical device or medical implement of claim 1 , wherein the impregnating liquid further comprises an additive to prevent or reduce evaporation of the impregnating liquid.

10. The medical device or medical implement of claim 1 , wherein the medical device or medical implement is a member selected from the group consisting of braces, dentures, a retainer, orthodonture, a bridge, an implant, a tooth/teeth mold, a prosthesis, an artificial organ, an artificial artery, a stent, a syringe, a lining, an IV tube, an IV bag, a colostomy bag, a surgical instrument, a bandage, and a blood pump.

11. The medical device or medical implement of claim 1 , wherein said medical device or medical implement is a blood pump or part thereof, wherein the surface is configured to provide reduction of shear forces to prevent damage to cells and/or other biological structures in blood or other biological fluids being pumped thereby or therethrough.

12. The medical device or medical implement of claim 1 , wherein said medical device or medical implement is a member selected from the group consisting of a pill, capsule, tablet, gel cap, and suppository.

13. The medical device or medical implement of claim 1 , wherein said medical device or medical implement is a member selected from the group consisting of a micropoipette, a small volume container of biological material, a human serum container, a pipette, a pipette tip, a microfluidic device, a dialysis machine, a tube, an endoscope, an intubation device, a syringe, a stent, a catheter, and a tracheotomy tube.

14. The medical device or medical implement of claim 1 , wherein said medical device or medical implement is a member selected from the group consisting of a glove, bandage, adhesive strip, drug release patch, and condom.

15. The medical device or medical implement of claim 1 , wherein said impregnating liquid is curable and can be converted to a solid by curing.

16. The medical device or medical implement of claim 3 , wherein 0<ϕ≤0.10.

17. The medical device or medical implement of claim 3 , wherein 0.01<ϕ≤0.25.

18. The medical device or medical implement of claim 3 , wherein 0.01<ϕ≤0.10.

19. The medical device or medical implement of claim 1 , wherein one or both of the following holds:
(i) θ os(w),receding =0; and
(ii) θ os(a),receding =0 and θ os(w),receding =0,
wherein θ os(w),receding is receding contact angle of the impregnating liquid (subscript ‘o’) on the surface (subscript ‘s’) in the presence of water (subscript ‘w’), and
wherein θ os(a),receding is receding contact angle of the impregnating liquid (subscript ‘o’) on the surface (subscript ‘s’) in the presence of air (subscript ‘a’).

20. The medical device or medical implement of claim 1 , wherein S ow(a) <0, where S ow(a) is spreading coefficient, defined as γ wa −γ wo −γ oa , where γ is the interfacial tension between the two phases designated by subscripts w, a, and o, where w is water, a is air, and o is the impregnating liquid.

21. The medical device or medical implement of claim 1 , wherein the surface prevents fibrosis and/or thrombosis on the medical device or medical implement.

22. The medical device or medical implement of claim 1 , wherein the medical device or medical implement is a catheter.

23. A method of forming the medical device or medical implement with high lubricity to flesh or biological fluid and/or inhibited nucleation on its surface of claim 1 , the method comprising:
applying an impregnating liquid to a plurality of micro-scale and/or nano-scale solid features on the surface of the medical device or medical implement such that the impregnating liquid fills in the spaces between said solid features with the impregnating liquid thereby forming a liquid-impregnated surface, wherein at least a portion of the micro-scale and/or nano-scale solid features are non-submerged by the impregnating liquid when the surf

Assignees

• Massachusetts Inst Technology

Inventors

• Smith J David
• Dhiman Rajeev
• Paxson Adam T
• Love Christopher J
• Solomon Brian R
• Varanasi Kripa K

Classifications

• A61L2400/18

  Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment · CPC title

• A61L2400/12

  Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces · CPC title

• A61L2400/10

  Materials for lubricating medical devices · CPC title

• A61L15/42

  Use of materials characterised by their function or physical properties (liquid bandages A61L26/00) · CPC title

• A61L15/34

  Oils, fats, waxes or natural resins {(A61L15/225 takes precedence)} · CPC title