Two-part nitric oxide generating topical compositions

Patent metadata

Field	Value
Publication number	US-11998513-B2
Application number	US-201916976382-A
Country	US
Kind code	B2
Filing date	Feb 28, 2019
Priority date	Mar 1, 2018
Publication date	Jun 4, 2024
Grant date	Jun 4, 2024

Abstract

A two-part topical composition includes a first composition including a S-nitrosothiol nitric oxide donor and a carrier, and a second composition including zinc oxide. The second composition is to be mixed with the first composition. The zinc oxide reacts with the S-nitrosothiol nitric oxide donor at a temperature ranging from about 20° C. to about 40° C. to enhance a rate of release of nitric oxide from a mixture of the first composition and the second composition.

First claim

What is claimed is:

1. A two-part topical composition, comprising:
a first composition including a S-nitrosothiol nitric oxide donor and a carrier, wherein the carrier includes petroleum jelly; and
a second composition including zinc oxide, the second composition to be mixed with the first composition at a weight ratio of 50:50 to 80:20;
wherein the zinc oxide is to react with the S-nitrosothiol nitric oxide donor at a temperature ranging from about 20° C. to about 40° C. to enhance a rate of release of nitric oxide from a mixture of the first composition and the second composition.

2. The two-part topical composition as defined in claim 1 wherein a concentration of the S-nitrosothiol nitric oxide donor in the first composition ranges from about 2.5 wt % to about 40 wt %.

3. The two-part topical composition as defined in claim 1 wherein a concentration of the zinc oxide in the second composition ranges from about 5 wt% to about 40 wt %.

4. The two-part topical composition as defined in claim 1 wherein:
the S-nitrosothiol nitric oxide donor is selected from the group consisting of S-nitroso-N-acetyl-penicillamine, S-nitrosoglutathione, and combinations thereof; and
the carrier is the petroleum jelly.

5. The two-part topical composition as defined in claim 1 wherein the second composition further includes mineral oil, petrolatum, beeswax, dimethicone, sorbitan sesquioleate, microcrystalline wax, PEG-30 dipolyhydroxy stearate, aloe barbadensis leaf extract, glycerin, tropolone, tocopheryl acetate, 1,2-hexanediol, caprylyl glycol, magnesium sulfate, potassium hydroxide, and phenoxyethanol.

6. The two-part topical composition as defined in claim 1 wherein the second composition further comprises a copper catalyst or an organoselenium catalyst.

7. A topical composition kit, comprising:
a first container having therein a first composition including a S-nitrosothiol nitric oxide donor and a carrier, wherein the carrier includes petroleum jelly; and
a second container having therein a second composition including zinc oxide, the second composition to be mixed with the first composition at a weight ratio of 50:50 to 80:20;
wherein the first and second containers respectively deliver effective amounts of the first and second compositions, wherein the zinc oxide reacts with the S-nitrosothiol nitric oxide donor at a temperature ranging from about 20° C. to about 40° C. to enhance a rate of release of nitric oxide from a mixture of the first composition and the second composition.

8. The topical composition kit as defined in claim 7 wherein the second composition further includes mineral oil, petrolatum, beeswax, dimethicone, sorbitan sesquioleate, microcrystalline wax, PEG-30 dipolyhydroxystearate, aloe barbadensis leaf extract, glycerin, tropolone, tocopheryl acetate, 1,2-hexanediol, caprylyl glycol, magnesium sulfate, potassium hydroxide, and phenoxyethanol.

9. The topical composition kit as defined in claim 7 wherein the effective amounts of the first composition to the second composition correspond to the weight ratio.

10. The topical composition kit as defined in claim 7 wherein a concentration of the S-nitrosothiol nitric oxide donor in the first composition ranges from about 2.5 wt % to about 40 wt %.

11. The topical composition kit as defined in claim 7 wherein a concentration of the zinc oxide in the second composition ranges from about 5 wt % to about 40 wt %.

12. The topical composition kit as defined in claim 7 wherein:
the S-nitrosothiol nitric oxide donor is selected from the group consisting of S-nitroso-N-acetyl-penicillamine, S-nitrosoglutathione, and combinations thereof; and
the carrier is the petroleum jelly.

13. A method for regulating nitric oxide release from a topical composition, the method comprising:
mixing an effective amount of a first composition including a S-nitrosothiol nitric oxide donor and a carrier that includes petroleum jelly with an effective amount of a second composition including zinc oxide to form a mixture, the effective amounts of the first composition to the second composition correspond to a weight ratio ranging from about 50:50 to about 20:80; and
heating the mixture to a temperature ranging from about 20° C. to about 40° C.

14. The method as defined in claim 13 wherein:
a concentration of the S-nitrosothiol nitric oxide donor in the first composition ranges from about 2.5 wt % to about 40 wt %.

15. The method as defined in claim 13 wherein:
the S-nitrosothiol nitric oxide donor is selected from the group consisting of S-nitroso-N-acetyl-penicillamine, S-nitrosoglutathione, and combinations thereof; and
the carrier is the petroleum jelly.

16. A method for treating a skin ailment, the method comprising:
mixing an effective amount of a first composition including a S-nitrosothiol nitric oxide donor and a carrier that includes petroleum jelly with an effective amount of a second composition including zinc oxide to form a mixture, the effective amounts of the first composition to the second composition correspond to a weight ratio ranging from about 50:50 to about 20:80; and
applying the mixture to skin, whereby the mixture is heated to a temperature ranging from about 20° C. to about 40° C. and the zinc oxide reacts with the S-nitrosothiol nitric oxide donor to enhance a rate of release of nitric oxide.

17. The two-part topical composition as defined in claim 1 wherein the carrier further includes an ointment containing bacitracin, neomycin, and polymyxin B in a base of cocoa butter, cotton seed oil, sodium pyruvate, tocopheryl acetate, and additional petroleum jelly.

18. The topical composition kit as defined in claim 7 wherein the carrier further includes an ointment containing bacitracin, neomycin, and polymyxin B in a base of cocoa butter, cotton seed oil, sodium pyruvate, tocopheryl acetate, and additional petroleum jelly.

19. The method as defined in claim 13 wherein the carrier further includes an ointment containing bacitracin, neomycin, and polymyxin B in a base of cocoa butter, cotton seed oil, sodium pyruvate, tocopheryl acetate, and additional petroleum jelly.

Assignees

• Univ Michigan Regents

Inventors

• Doverspike Joshua C
• Phan James
• Wu Jianfeng
• Xi Chuanwu
• Qin Yu
• Meyerhoff Mark E
• Zhou Yang

Classifications

• A61K31/04 Primary

  Nitro compounds · CPC title

• A61K31/198

  Alpha-amino acids, e.g. alanine or edetic acid [EDTA] (betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00) · CPC title

• A61K33/30

  Zinc; Compounds thereof · CPC title

• A61K38/063

  Glutathione · CPC title

• A61K47/06

  Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite · CPC title