Combination therapy of a type ii anti-cd20 antibody with a selective bcl-2 inhibitor
US-2017281619-A1 · Oct 5, 2017 · US
US9302085B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9302085-B2 |
| Application number | US-71263610-A |
| Country | US |
| Kind code | B2 |
| Filing date | Feb 25, 2010 |
| Priority date | Mar 11, 2009 |
| Publication date | Apr 5, 2016 |
| Grant date | Apr 5, 2016 |
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Provided are methods and compositions for locally increasing arterial diameter and providing local anesthesia in a subject. The methods include applying to a skin site of the subject a topical composition that includes a vasodilation agent and an anesthetic agent in a manner sufficient for locally increasing arterial diameter and providing local anesthesia in the subject. In some embodiments, the method includes inserting a cannula into an artery at the skin site of the subject. Also provided are topical compositions that find use in performing the subject methods.
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That which is claimed is: 1. A method for locally increasing arterial diameter and providing local anesthesia in a subject, the method comprising applying to a skin site of the subject a topical composition comprising a vasodilation agent in an amount ranging from 22.5 mg to 75 mg and an anesthetic agent in a manner sufficient for locally increasing diameter and providing local anesthesia in the subject without producing a significant systemic effect in the subject, wherein the vas…
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