Radioactive liquid embolic

Patent metadata

Field	Value
Publication number	US-11992575-B2
Application number	US-202016750635-A
Country	US
Kind code	B2
Filing date	Jan 23, 2020
Priority date	Oct 9, 2017
Publication date	May 28, 2024
Grant date	May 28, 2024

Abstract

Liquid embolic preparations and medical treatment methods of using those preparations are described. In some embodiments, the preparations or solutions can transition from a liquid to a solid for use in the embolization. The preparations can include biocompatible polymers with covalently bound radioactive iodine isotopes.

First claim

We claim:

1. A polymeric composition, comprising a non-physiological solution, and a folate-polymer conjugate that is a reaction product of:
1) A biocompatible polymer comprising a reaction product of:
a first monomer including a polymerizable moiety having a biodegradable linkage to a visualization agent having at least one aromatic ring, wherein the at least one aromatic ring includes at least one iodine atom, wherein at least one of the at least one iodine atom is a radioactive isotope,
and a second monomer comprising hydroxyethyl methacrylate; and

2) A folate compound having the formula:

wherein n is 0-100;
wherein the folate compound is conjugated to the hydroxy moiety of the hydroxyethyl methacrylate;
wherein the folate-polymer conjugate is soluble in the non-physiological solution and insoluble in a physiological solution; and
wherein the folate-polymer conjugate comprises the formula:

wherein n is 0-100.

2. The polymeric composition of claim 1 , wherein the biodegradable linkage is SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 8, SEQ ID NO: 9, SEQ ID NO: 10, SEQ ID NO: 11, or SEQ ID NO: 12.

3. The polymeric composition of claim 1 , wherein n is 1, 2, 3, 4, 5, 6, or 100.

4. The polymeric composition of claim 1 , wherein the radioactive isotope is 123 I, 124 I, 125 I, 131 I, or a combination thereof.

5. The polymeric composition of claim 1 , wherein the radioactive isotope is 123 I.

6. The polymeric composition of claim 1 , wherein the radioactive isotope is 124 I.

7. The polymeric composition of claim 1 , wherein the radioactive isotope is 125 I.

8. The polymeric composition of claim 1 , wherein the radioactive isotope is 131 I.

9. The polymeric composition of claim 1 , wherein the first monomer is functionalized triiodophenol, 1-((2-(methacryloyloxy)ethoxy)carbonyloxy)ethyl-3,5-diacetamido-2,4,6-triiodobenzoate, 2-oxo-2-(1-oxo-1-(1-oxo-1-(2,4,6-triiodophenoxy)propan-2-yloxy)propan-2-yloxy)ethoxy)ethyl acrylate, or a combination thereof.

10. The polymeric composition of claim 1 , wherein n is 1.

11. A polymeric composition, comprising a non-physiological solution and a folate-polymer conjugate, wherein:
the folate-polymer conjugate comprises a visualization agent having at least one aromatic ring, wherein the at least one aromatic ring includes at least one iodine atom, wherein at least one of the at least one iodine atom is a radioactive isotope,
the folate-polymer conjugate comprises the formula:

wherein n is 0-100; and
the folate-polymer conjugate is soluble in the non-physiological solution and insoluble in a physiological solution.

12. The polymeric composition of claim 11 , wherein n is 1, 2, 3, 4, 5, 6, or 100.

13. The polymeric composition of claim 11 , wherein n is 1.

Assignees

• Microvention Inc

Inventors

• Cruise Gregory M
• Wu Xinping
• Fitz Matthew J
• Wu Yue

Classifications

• A61L24/0005 Primary

  Ingredients of undetermined constitution or reaction products thereof · CPC title

• A61L24/001

  Use of materials characterised by their function or physical properties · CPC title

• A61L24/0015 Primary

  Medicaments; Biocides · CPC title

• A61L2300/428

  Vitamins, e.g. tocopherol, riboflavin · CPC title

• A61L2300/44

  Radioisotopes, radionuclides · CPC title