Polymeric treatment compositions

Patent metadata

Field	Value
Publication number	US-2016243157-A1
Application number	US-201615142395-A
Country	US
Kind code	A1
Filing date	Apr 29, 2016
Priority date	Jun 14, 2012
Publication date	Aug 25, 2016
Grant date	—

Abstract

Compositions are described comprising a polymer; a non-physiological pH solution; and a visualization agent; wherein the polymer is soluble in the non-physiological pH solution and insoluble at a physiological pH. Methods of forming the solutions and polymers are disclosed as well as methods of therapeutic use.

First claim

We claim:

1 . A method of delivering a composition comprising:
injecting through a delivery device into a location with physiological pH environment a liquid embolic composition comprising a polymer, a non-physiological pH solution and a visualization agent, wherein the polymer precipitates when it reaches the physiological pH.

2 . The method of claim 1 , wherein the visualization agent is a particulate.

3 . The method of claim 1 , wherein the visualization agent has a concentration of about 5% to about 65%.

4 . The method of claim 1 , wherein the visualization agent is an iodinated compound or barium sulfate.

5 . The method of claim 1 , wherein the polymer is a reaction product of two different monomers.

6 . The method of claim 1 , wherein the polymer is a reaction product of three different monomers.

7 . The method of claim 1 , wherein the non-physiological pH solution is aqueous.

8 . The method of claim 1 , wherein the non-physiological pH solution has a pH of less than about 5.

9 . The method of claim 1 , wherein the non-physiological pH solution has a pH of greater than about 8.

10 . The method of claim 1 , wherein the polymer has a concentration of about 1% w/w to about 35% w/w.

11 . A method of treating a vascular disorder comprising
providing a liquid embolic composition comprising a biocompatible polymer, a non-physiological pH solution and a visualization agent, wherein the biocompatible polymer is soluble in the non-physiological pH solution and insoluble in a physiological pH; inserting a delivery device into a vessel; guiding the delivery device to an area in need of treatment wherein the area has a physiological pH; injecting the liquid embolic polymer composition through the delivery device into the vessel at the area in need of treatment thereby immediately precipitating the polymer and forming a solid polymeric mass; and treating the vascular condition.

12 . The method of claim 11 , wherein the visualization agent is a particulate.

13 . The method of claim 11 , wherein the visualization agent has a concentration of about 5% to about 65%.

14 . The method of claim 11 , wherein the visualization agent is an iodinated compound or barium sulfate.

15 . The method of claim 11 , wherein the biocompatible polymer is a reaction product of two different monomers.

16 . The method of claim 11 , wherein the biocompatible polymer is a reaction product of three different monomers.

17 . The method of claim 11 , wherein the non-physiological pH solution is aqueous.

18 . The method of claim 11 , wherein the non-physiological pH solution has a pH of less than about 5.

19 . The method of claim 11 , wherein the non-physiological pH solution has a pH of greater than about 8.

20 . The method of claim 11 , wherein the biocompatible polymer has a concentration of about 1% w/w to about 35% w/w.

Assignees

• Microvention Inc

Inventors

• Cruise Gregory M
• Constant Michael J
• Garretson Joshua

Classifications

• A61P9/00

  Drugs for disorders of the cardiovascular system · CPC title

• A61K31/78

  of acrylic acid or derivatives thereof · CPC title

• A61K9/08

  Solutions {(composition of solutions A61K47/00)} · CPC title

• A61L24/046

  obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds (A61L24/043 takes precedence) · CPC title

• A61L2430/36

  for embolization or occlusion, e.g. vaso-occlusive compositions or devices · CPC title