Spring loaded medical device

Patent metadata

Field	Value
Publication number	US-11992425-B2
Application number	US-202016832300-A
Country	US
Kind code	B2
Filing date	Mar 27, 2020
Priority date	Mar 29, 2019
Publication date	May 28, 2024
Grant date	May 28, 2024

Abstract

A structure is provided comprising a number of surfaces 10, 20 joined together with an adhesive 30, said structure being configured to reshape upon at least partial degradation of the adhesive 30. Related method and uses are further provided.

First claim

The invention claimed is:

1. A structure, comprising:
a plurality of surfaces; and
an adhesive layer, as an Atomic Layer Deposition (ALD) coating layer of thickness 0.1-100 nm on all surfaces of the structure,
wherein the plurality of surfaces are joined together by the adhesive layer in a first configuration having a collapsed shape,
wherein the structure in the first configuration bears a mechanical load resulting from the adhesive layer joining said plurality of surfaces together and forming the collapsed shape, and
wherein the adhesive layer is configured to at least partially degrade and thereby permit the plurality of surfaces to detach from one another and release the mechanical load, the structure configured so that when the mechanical load is released the structure reshapes itself from the collapsed shape into a second configuration having an original shape corresponding to a shape the structure had prior to the surfaces being joined together by the adhesive layer.

2. The structure of claim 1 , wherein the adhesive layer is biocompatible and/or biodegradable.

3. The structure of claim 1 , configured as a medical device.

4. The structure of claim 1 , configured as an implantable medical device.

5. The structure of claim 1 , configured as a stent.

6. The structure of claim 1 , configured for a gradual release of the mechanical load by modulating a degradation rate of the adhesive layer.

7. The structure of claim 1 , configured to release at least one chemical substance upon being reshaped due to at least partial degradation of the adhesive layer.

8. The structure of claim 7 , wherein the chemical substance comprises at least one pharmaceutically active agent.

9. The structure of claim 1 , wherein the adhesive layer comprises at least one ALD-deposited coating layer made of any of aluminium oxide (Al 2 O 3 ), magnesium oxide (MgO), and silicon dioxide (SiO 2 ).

10. The structure of claim 1 , formed of a mesh wire.

11. The structure of claim 1 , wherein the pre-applied mechanical load is a spring load.

12. A method for manufacturing a structure, comprising:
obtaining a structure having a plurality of surfaces, said structure configured to have an original shape;
applying an adhesive to all surfaces of the structure by Atomic Layer Deposition (ALD); and
joining said surfaces together with the adhesive so that said structure assumes a collapsed shape different from said original shape,
wherein the structure is configured to bear a mechanical load when in the collapsed shape and held by the adhesive, and
wherein the adhesive is configured to at least partially degrade in order to permit release of the mechanical load and thereby cause the collapsed structure to reshape and acquire the original shape that the structure had prior to the surfaces being joined together.

13. A method for delivering at least one pharmaceutically active agent into the body, wherein said at least one pharmaceutically active agent is provided in a structure comprising a plurality of surfaces joined together with an adhesive provided in the form of a coating layer applied by Atomic Layer Deposition (ALD),
wherein said structure is configured to release said pharmaceutically active agent upon at least partial degradation of the adhesive in the body.

14. The method of claim 13 , wherein the structure is configured to release said at least one pharmaceutically active agent upon being reshaped by virtue of at least partial degradation of the adhesive in the body.

15. A medical device comprising the structure of claim 1 .

16. The medical device of claim 15 , wherein the medical device is implantable.

Assignees

• Picosun Oy

Inventors

• Pudas Marko
• Oksala Niku

Classifications

• A61F2/82 Primary

  Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents (stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07) · CPC title

• A61F2210/0004

  bioabsorbable · CPC title

• A61F2220/005

  using adhesives · CPC title

• A61F2240/001

  Designing or manufacturing processes · CPC title

• A61F2250/0031

  made from both resorbable and non-resorbable prosthetic parts, e.g. adjacent parts · CPC title