Systems and methods for use and control of an automated separator with adsorption columns

Patent metadata

Field	Value
Publication number	US-11938259-B2
Application number	US-201916529901-A
Country	US
Kind code	B2
Filing date	Aug 2, 2019
Priority date	Apr 13, 2011
Publication date	Mar 26, 2024
Grant date	Mar 26, 2024

Abstract

Blood treatment systems and methods are provided for combining a blood separation system and an adsorption device. The blood separation system is configured to separate a blood component from blood, while the adsorption device is configured to receive at least a portion of the separated blood component and process it. The blood separation system includes a fluid flow element and a controller. The fluid flow element is configured for flowing the separated blood component into the adsorption device. The controller controls the fluid flow element based at least in part on one or more processing parameters. The processing parameters include a maximum flow rate of the separated blood component flowed into the adsorption device, a maximum pressure of the separated blood component flowed into the adsorption device, and/or the volume of fluid in a location of the system.

First claim

The invention claimed is:

1. A blood treatment system comprising, in combination:
a blood separation system configured to separate at least one blood component from blood; and
an adsorption device configured to receive at least a portion of said at least one blood component from the blood separation system, wherein
each of the blood separation system and the adsorption device includes a fluid flow element, with the fluid flow element of the blood separation system being configured for flowing said at least one blood component to a location and the fluid flow element of the adsorption device configured for flowing said at least a portion of said at least one blood component from said location into the adsorption device, and
the blood separation system includes a controller programmed to control the fluid flow element of the blood separation system based at least in part on one or more characteristics of said location.

2. The blood treatment system of claim 1 , wherein the controller is programmed to control the fluid flow element of the blood separation system based at least in part on a volume of fluid in said location.

3. The blood treatment system of claim 1 , wherein the controller is programmed to control the fluid flow element of the blood separation system based at least in part on one or more processing parameters including a maximum flow rate of said at least a portion of said at least one blood component flowed into the adsorption device and/or a maximum pressure of said at least a portion of said at least one blood component flowed into the adsorption device.

4. The blood treatment system of claim 1 , wherein the fluid flow element of the adsorption device operates independently of the controller.

5. The blood treatment system of claim 1 , wherein said location comprises a pre-adsorption reservoir.

6. The blood treatment system of claim 1 , further comprising a second fluid flow element of the blood separation system and a second location, wherein
the fluid flow element of the adsorption device is configured to flow processed fluid out of the adsorption device and into the second location,
the second fluid flow element of the blood separation device is configured to flow the processed fluid out of the second location, and
the controller is programmed to control the second fluid flow element of the blood separation system based at least in part on one or more characteristics of said second location.

7. The blood treatment system of claim 6 , wherein the controller is programmed to control the second fluid flow element of the blood separation system based at least in part on a volume of fluid in said second location.

8. The blood treatment system of claim 6 , wherein said second location comprises a post-adsorption reservoir.

9. The blood treatment system of claim 1 , further comprising a disposable flow circuit including
a blood separation chamber in which said at least one blood component is separated from blood,
at least one cassette fluidly connected between the blood separation chamber and the adsorption device and including a plurality of valve stations configured to be actuated by the blood separation system to direct fluid flow through the at least one cassette, and
a plurality of containers fluidly connected to the at least one cassette, wherein
the fluid flow element of the blood separation system is configured to actuate the at least one cassette for flowing said at least one blood component from the blood separation chamber continuously to said location, and
the blood separation system includes a plurality of valve actuators each configured to alternately open and close an associated one of the plurality of valve stations to change the fluid flow through the at least one cassette.

10. The blood treatment system of claim 1 , wherein
the at least one blood component is separated from blood in a blood separation chamber, and
the controller is programmed to control the fluid flow element of the blood separation system to operate at a maximum flow rate equal to a smallest of a flow rate at which the blood enters the blood separation chamber, a flow rate at which said at least one blood component exits the blood separation chamber, and a maximum allowable flow rate at which fluid may enter the adsorption device.

11. A blood treatment system comprising, in combination:
a blood separation system configured to separate at least one blood component from blood in a blood separation chamber; and
an adsorption device configured to receive at least a portion of said at least one blood component from the blood separation system, wherein
each of the blood separation system and the adsorption device includes a fluid flow element, with the fluid flow element of the blood separation system being configured for flowing said at least one blood component to a location and the fluid flow element of the adsorption device configured for flowing said at least a portion of said at least one blood component from said location into the adsorption device,
the blood separation system includes a controller programmed to control the fluid flow element of the blood separation system based at least in part on one or more characteristics of said location,
the controller is programmed to control the fluid flow element of the blood separation system to operate at a maximum flow rate equal to a smallest of a flow rate at which the blood enters the blood separation chamber, a flow rate at which said at least one blood component exits the blood separation chamber, and a maximum allowable flow rate at which fluid may enter the adsorption device, and
the controller is programmed to apply an adjustment factor between 0 and 1 to the flow rate at which the fluid flow element of the blood separation system operates, with an adjustment factor of 0 corresponding to the fluid flow element of the blood separation system being deactivated, an adjustment factor of 1 corresponding to the fluid flow element of the blood separation system operating at the maximum flow rate, and an adjustment factor between 0 and 1 corresponding to the fluid flow element of the blood separation system operating at a flow rate that is less than the maximum flow rate.

12. The blood treatment system of claim 1 , wherein the adsorption device includes a plurality of adsorption columns.

13. The blood treatment system of claim 12 , wherein
the adsorption device includes a plurality of fluid flow elements, and
each adsorption column includes a different associated fluid flow element to define a plurality of adsorption column-fluid flow element pairs.

14. The blood treatment system of claim 13 , wherein the adsorption device includes a controller programmed to switch between operation of the plurality of adsorption column-fluid flow element pairs.

15. A blood treatment system comprising, in combination:
a blood separation system configured to separate at least one blood component from blood; and
an adsorption device configured to receive at least a portion of said at least one blood component from the blood separation system, wherein
each of the blood separation system and the adsorption device includes a fluid flow element, with the fluid flow element of the blood separation system being configured for flowing said at least one blood component to a location and the fluid flow element of the adsorption device configured for flowing said at least a portion of said at least one blood component from said location into the adsorption device,
the blood separation system includes a controller programmed to control the fluid flow element of the blood separati

Assignees

• Fenwal Inc

Inventors

• Foley John T
• Prendergast Jonathan
• Nguyen Lan T
• Case Brian C

Classifications

• A61M1/362 Primary

  changing physical properties of target cells by binding them to added particles to facilitate their subsequent separation from other cells, e.g. immunoaffinity · CPC title

• A61M1/362227

  the interface providing means for actuating on functional elements of the cassette, e.g. plungers · CPC title

• A61M1/36224

  with sensing means or components thereof · CPC title

• A61M1/36225

  with blood pumping means or components thereof · CPC title

• A61M1/362261

  at least one cassette surface or portion thereof being flexible, e.g. the cassette having a rigid base portion with preformed channels and being covered with a foil · CPC title