Systems and methods for parallel channel microfluidic separation

Patent metadata

Field	Value
Publication number	US-10099002-B2
Application number	US-201514815501-A
Country	US
Kind code	B2
Filing date	Jul 31, 2015
Priority date	Jul 31, 2014
Publication date	Oct 16, 2018
Grant date	Oct 16, 2018

Abstract

The present disclosure describes a system and method for microfluidic separation. More particularly, the disclosure describes a system and method for the purification of a fluid by the removal of undesired particles. The device includes microfluidic separation channels that include multiple outlets. The device also includes isolation slots positioned between each of the microfluidic separation channels. The device's base includes multiple acoustic transducers which in some implementations are configured to protrude into the isolation slots. The acoustic transducers are configured to generate aggregation axes within the separation channels, which are used to separate out undesired particles.

First claim

The invention claimed is:

1. A separation device comprising:
a plastic substrate defining:
a plurality of microfluidic separation channels each having an upstream portion and a downstream portion, the upstream portion comprising an inlet and the downstream portion comprising at least a first outlet and a second outlet; and
one or more isolation slots, one of the one or more isolation slots positioned between each of the plurality of microfluidic separation channels; and

a base substrate coupled to the plastic substrate and comprising one or more acoustic transducers, each of the one or more acoustic transducers coupled to a wall of one or more of the respective plurality of microfluidic separation channels.

2. The device of claim 1 , wherein each of the one or more acoustic transducers protrude perpendicular to a face of the base substrate and into a respective one of the one or more isolation slots.

3. The device of claim 1 , wherein the first outlet of each of the plurality of microfluidic separation channels is positioned substantially along a longitudinal axis of the respective microfluidic separation channel.

4. The device of claim 1 , wherein the second outlet of each of the plurality of microfluidic separation channels is positioned adjacent to a wall of the respective microfluidic separation channel.

5. The device of claim 1 , wherein each of the plurality of microfluidic separation channels further comprise:
a first wall having a first thickness; and
a second wall opposite the first wall and having a second thickness.

6. The device of claim 5 , wherein the first thickness and the second thickness are about equal to c s (f)/4f, or an odd multiple thereof, where c s (f) is a frequency dependent speed of a shear wave through the plastic.

7. The device of claim 5 , wherein the second thickness is different than the first thickness.

8. The device of claim 7 , wherein the first thickness is about c w /4f+d, the second thickness is about c w (f)/4f−d, and a lateral width of each of the of microfluidic separation channels is about c f /2f, where c w is an odd multiple of an acoustic velocity of an acoustic wave in the plastic substrate, c f is an acoustic velocity of the acoustic wave in a fluid flowing through each of the plurality of microfluidic separation channels, f is an operating frequency of the acoustic wave, and d is a width increment defined by c f /16f<d<c f /4f.

9. The device of claim 1 , wherein each of one or more isolation slots run substantially parallel to and the entire length of the plurality of microfluidic separation channels.

10. The device of claim 1 , wherein one or more isolation slots each have a height equal to a thickness of the plastic substrate.

11. The device of claim 1 , further comprising a manifold configured to distribute a fluid to the inlet of each of the plurality of microfluidic separation channels.

12. The device of claim 11 , wherein the manifold comprises a network of biomimetic channels.

13. A separation device comprising:
a first separation channel defined in a plastic substrate, the first separation channel having an upstream portion and a downstream portion;
the upstream portion comprising an inlet; and
the downstream portion comprising a first outlet positioned along a first wall and a second outlet positioned along a second wall, wherein the thickness of the first wall is different than the thickness of the second wall;

a second separation channel defined in the plastic substrate, the second separation channel adjacent to the first separation channel; and
an isolation slot defined in the plastic substrate, the isolation slot positioned between the second separaton channel and the first separation channel.

14. The device of claim 13 , further comprising a base substrate coupled to the plastic substrate, the base substrate comprising an acoustic transducer.

15. The device of claim 13 , wherein the first thickness is about c w /4f+d, the second thickness is about c w /4f−d, and a lateral width of each of the of microfluidic separation channels is about c f /2f, where c w is an odd multiple of an acoustic velocity of an acoustic wave in the plastic substrate, c f is an acoustic velocity of the acoustic wave in a fluid flowing through each of the plurality of microfluidic separation channels, f is an operating frequency of the acoustic wave, and d is a width increment defined by c f /16f<d<c f /4f.

Assignees

• Charles Stark Draper Laboratory Inc

Inventors

• Sun Hoi-Cheong Steve
• Fiering Jason Oliver

Classifications

• A61M1/3693 Primary

  using separation based on different densities of components, e.g. centrifuging · CPC title

• A61M1/3678

  Separation of cells using wave pressure; Manipulation of individual corpuscles · CPC title

• A61M1/3687

  Chemical treatment (A61M1/3675 takes precedence) · CPC title

• B01D2221/10

  Separation devices for use in medical, pharmaceutical or laboratory applications, e.g. separating amalgam from dental treatment residues · CPC title

• B01D21/283

  Settling tanks provided with vibrators · CPC title