Organic and inorganic test system

Patent metadata

Field	Value
Publication number	US-11935397-B2
Application number	US-201916730118-A
Country	US
Kind code	B2
Filing date	Dec 30, 2019
Priority date	Dec 30, 2019
Publication date	Mar 19, 2024
Grant date	Mar 19, 2024

Abstract

A test system includes a test container array including a plurality of test containers and a plurality of electrodes integrated into the test container array. The test system further includes a plurality of drive-sense circuits coupled to the plurality of electrodes, where, when enabled, the plurality of drive-sense circuits detect changes in electrical characteristics of the plurality of electrodes. The test system further includes a processing module operably coupled to receive, from the drive-sense circuits, changes in the electrical characteristics of the plurality of electrodes, and interpret the changes in the electrical characteristics of the plurality of electrodes as impedance values representative of electrical characteristics of biological material present in the test container. The test system further includes a communication module operably coupled to communicate the electrical characteristics of the biological material.

First claim

What is claimed is:

1. A test system comprises:
a test container array including a plurality of test containers;
a plurality of electrodes integrated into the test container array, wherein a set of electrodes of the plurality of electrodes is integrated into a test container of the test container array;
a plurality of drive-sense circuits coupled to the plurality of electrodes, wherein a set of drive-sense circuits of the plurality of drive-sense circuits is coupled to the set of electrodes, wherein an electrode of the set of electrodes is coupled to a drive-sense circuit of the set of the drive-sense circuits via a single line and wherein the drive-sense circuit is operable to simultaneously both drive and detect a change in electrical characteristics of the electrode via the single line;
a processing module operably coupled to:
receive, from the set of drive-sense circuits, a set of changes in electrical characteristics of the set of electrodes; and
interpret the set of changes in electrical characteristics of the set of electrodes as a set of impedance values representative of electrical characteristics of biological material present in the test container; and

a communication module operably coupled to communicate the electrical characteristics of the biological material.

2. The test system of claim 1 , wherein the biological material comprises one or more of:
one or more biological cells; and
a portion of one or more biological cells.

3. The test system of claim 1 , wherein the electrical characteristics of the biological material include one or more of:
position;
impedance;
size;
shape;
movement;
density;
excitability; and
potential.

4. The test system of claim 1 , wherein the processing module is operable to interpret the set of changes in electrical characteristics as the set of impedance values by:
receiving, from the set of drive-sense circuits, the set of changes in electrical characteristics from the set of electrodes;
filtering the set of changes in electrical characteristics in accordance with a set of bandpass frequency ranges to produce a set of filtered signals; and
interpreting the set of filtered signals to identify the set of impedance values representative of the electrical characteristics of the biological material.

5. The test system of claim 1 further comprises:
a plurality of multiplexors coupled to the plurality of drive-sense circuits and the plurality of electrodes, wherein a first multiplexor of the plurality of multiplexors is coupled to a first drive sense-circuit of the plurality of drive-sense circuits and the set of electrodes; and
the processing module is further operable to:
generate a plurality of multiplexor control signals for selecting electrodes of the plurality of electrodes for sensing via the plurality of drive-sense circuits, wherein a first multiplexor control signal of the plurality of multiplexor control signals selects a first electrode of the set of electrodes for sensing via the first drive-sense circuit.

6. A test system comprises:
a test container array including a plurality of test containers;
a plurality of electrodes integrated into the test container array, wherein a set of electrodes of the plurality of electrodes is integrated into a test container of the test container array;
a plurality of drive-sense circuits coupled to the plurality of electrodes, wherein a set of drive-sense circuits of the plurality of drive-sense circuits is coupled to the set of electrodes, wherein an electrode of the set of electrodes are coupled to a drive-sense circuit of the set of the drive-sense circuits via a single line, wherein the drive-sense circuit is operable to simultaneously both drive and detect a change in electrical characteristics of the electrode via the single line, and wherein the change in the electrical characteristics are representative of electrical characteristics of biological material present in the test container; and
a communication module operably coupled to communicate the electrical characteristics of the electrode.

7. The test system of claim 6 further comprises:
a processing module operably coupled to:
receive, from the set of drive-sense circuits, a set of changes in electrical characteristics of the set of electrodes; and

interpret the set of changes in electrical characteristics of the set of electrodes as a set of impedance values representative of electrical characteristics of the biological material present in the test container.

8. The test system of claim 7 , wherein the processing module is operable to interpret the set of changes in electrical characteristics as the set of impedance values by:
receiving, from the set of drive-sense circuits, the set of changes in electrical characteristics from the set of electrodes;
filtering the set of changes in electrical characteristics in accordance with a set of bandpass frequency ranges to produce a set of filtered signals; and
interpreting the set of filtered signals to identify the set of impedance values representative of the electrical characteristics of the biological material.

9. The test system of claim 7 further comprises:
a plurality of multiplexors coupled to the plurality of drive-sense circuits and the plurality of electrodes, wherein a first multiplexor of the plurality of multiplexors is coupled to a first drive sense-circuit of the plurality of drive-sense circuits and the set of electrodes; and
the processing module is further operable to:
generate a plurality of multiplexor control signals for selecting electrodes of the plurality of electrodes for sensing via the plurality of drive-sense circuits, wherein a first multiplexor control signal of the plurality of multiplexor control signals selects a first electrode of the set of electrodes for sensing via the first drive-sense circuit.

10. The test system of claim 6 , wherein the biological material comprises one or more of:
one or more biological cells; and
a portion of one or more biological cells.

11. The test system of claim 6 , wherein the electrical characteristics of the biological material include one or more of:
position;
impedance;
size;
shape;
movement;
density;
excitability; and
potential.

Assignees

• Sigmasense Llc

Inventors

• Van Ostrand Daniel Keith
• Seger Jr Richard Stuart
• Morrison Gerald Dale
• Gray Patrick Troy
• Huynh Phuong
• Markison Timothy W
• Markison Patricia A

Classifications

• G08C15/02 Primary

  simultaneously, i.e. using frequency division · CPC title

• G01D21/02

  Measuring two or more variables by means not covered by a single other subclass · CPC title

• G01N27/028 Primary

  Circuits therefor (measuring impedance per se G01R27/02) · CPC title

• G01N33/4836 Primary

  using multielectrode arrays · CPC title

• B01L3/5085

  for multiple samples, e.g. microtitration plates · CPC title