Device and method for generating droplets

Patent metadata

Field	Value
Publication number	US-11872533-B2
Application number	US-201816498002-A
Country	US
Kind code	B2
Filing date	Mar 22, 2018
Priority date	Mar 27, 2017
Publication date	Jan 16, 2024
Grant date	Jan 16, 2024

Abstract

The invention relates to a device (1) for generating droplets (30) comprising a plurality of channels (20), wherein each channel (20) extends from an inlet (201) along a respective longitudinal axis (L) to an outlet (202), wherein said device (1) comprises a plurality of layers (10) of a substrate material arranged in a stack (100), wherein each layer (10) comprises a first side (101) and a second side (102) facing away from each other, and wherein said first side (101) of each layer (10) comprises a plurality of grooves (103), wherein said channels (20) are formed by said grooves (103) of said first side (101) of a respective layer (10) of said stack (100) and said second side (102) of a respective adjacent layer (10) of said stack (100). The invention further relates to a method for generating droplets (30) and a fabrication method of the device (1).

First claim

The invention claimed is:

1. A device ( 1 ) for generating droplets ( 30 ) of a dispersed phase (D) in a continuous phase (C), comprising a plurality of channels ( 20 ), wherein each channel ( 20 ) comprises an inlet ( 201 ) and an outlet ( 202 ), and wherein each channel ( 20 ) extends from said inlet ( 201 ) along a respective longitudinal axis (L) to said outlet ( 202 ), so that droplets ( 30 ) of a dispersed phase (D) can be generated in a continuous phase (C) at said outlets ( 202 ) when a flow of said dispersed phase (D) from said inlets ( 201 ) to said outlets ( 202 ) is provided and said outlets ( 202 ) are in flow connection with a reservoir or conduit containing said continuous phase (C),
characterized in that
said device ( 1 ) comprises a plurality of layers ( 10 ) of a substrate material arranged in a stack ( 100 ), wherein each layer ( 10 ) comprises a first side ( 101 ) and a second side ( 102 ), wherein the first side ( 101 ) faces away from the second side ( 102 ), and wherein the first side ( 101 ) of each layer ( 10 ) comprises a plurality of grooves ( 103 ), wherein the grooves ( 103 ) of each first side ( 101 ) are covered by a second side ( 102 ) of an adjacent layer ( 10 ), such that said plurality of channels ( 20 ) is formed, wherein the inlets ( 201 ) are arranged on a front side ( 104 ) of the stack ( 100 ) and the outlets ( 202 ) are arranged on an opposing back side ( 105 ) of the stack ( 100 ), wherein each of the channels ( 20 ) comprises a nozzle ( 21 ) ending with the respective outlet ( 202 ), the outlet ( 202 ) comprising a first maximum cross sectional extension (e 1 ) of the nozzle ( 21 ), and wherein the respective channel ( 20 ) comprises a second cross-sectional extension (e 2 ) adjacent the respective nozzle ( 21 ), wherein said first maximum cross-sectional extension (e 1 ) is larger than said second cross-sectional extension (e 2 ).

2. The device ( 1 ) according to claim 1 , characterized in that said front side ( 104 ) and said back side ( 105 ) extend perpendicular to the layers ( 10 ) of the stack ( 100 ).

3. The device ( 1 ) according to claim 1 , characterized in that each channel ( 20 ) comprises a respective aspect ratio (a) between a length (I) of the respective channel ( 20 ) along said longitudinal axis (L) and a minimum cross-sectional extension (e min ) perpendicular to said longitudinal axis (L), wherein said aspect ratio (a) is one of: at least 30, at least 75, or at least 120.

4. The device ( 1 ) according to claim 1 , characterized in that said aspect ratio (a) is one of: 30 to 20000, 75 to 20000, or 120 to 20000.

5. The device ( 1 ) according to claim 1 , characterized in that the device ( 1 ) comprises one of: at least 100 channels ( 20 ) or at least 1000 channels ( 20 ).

6. The device ( 1 ) according to claim 1 , characterized in that said stack ( 100 ) comprises at least 10 layers ( 10 ).

7. The device ( 1 ) according to claim 1 , characterized in that the channels ( 20 ) are parallel.

8. The device ( 1 ) according to claim 1 , characterized in that the cross-sectional extension of the channels ( 20 ) is one of: 200 μm or less, 50 μm or less, 25 μm or less, or 10 μm or less.

9. The device ( 1 ) according to claim 1 , characterized in that the device ( 1 ) further comprises a first reservoir or conduit ( 11 ) which is in flow connection with said inlets ( 201 ) of said channels ( 20 ) and a second reservoir or conduit ( 12 ) which is in flow connection with said outlets ( 202 ) of said channels ( 20 ).

10. The device ( 1 ) according to claim 9 , characterized in that said device ( 1 ) comprises at least one additional reservoir or conduit ( 13 ), wherein said device ( 1 ) comprises a plurality of first channels ( 20 a ) connecting said first reservoir or conduit ( 11 ) to said at least one additional reservoir or conduit ( 13 ), and wherein said device ( 1 ) comprises a plurality of second channels ( 20 b ) connecting said at least one additional reservoir or conduit ( 13 ) to said second reservoir or conduit ( 12 ).

11. A method for generating droplets ( 30 ) of a dispersed phase (D) in a continuous phase (C) comprising providing a device ( 1 ) according to claim 1 , wherein a flow of said dispersed phase (D) from said inlets ( 201 ) through said outlets ( 202 ) of said channels ( 20 ) into said continuous phase (C) is provided, and wherein a plurality of droplets ( 30 ) of said dispersed phase (D) is formed in said continuous phase (C).

12. The method according to claim 11 , wherein a flow of a dispersed inner phase (D 1 ) from inlets ( 201 ) through respective outlets ( 202 ) of a plurality of first channels ( 20 a ) of the device ( 1 ) into a dispersed middle phase (D 2 ) is provided, wherein a plurality of first droplets ( 31 ) of the dispersed inner phase (D 1 ) is formed in the dispersed middle phase (D 2 ), and wherein a flow of the dispersed middle phase (D 2 ) containing said first droplets ( 31 ) from inlets ( 201 ) through respective outlets ( 202 ) of a plurality of second channels ( 20 b ) of the device ( 1 ) into said continuous phase (C) is provided, wherein a plurality of second droplets ( 32 ) of said dispersed inner phase (D 1 ) and said dispersed middle phase (D 2 ) is formed in said continuous phase (C).

13. A method for fabricating a device ( 1 ) according to claim 1 , wherein a plurality of layers ( 10 ) of a substrate material is provided, and wherein a plurality of grooves ( 103 ) is generated in a respective first side ( 101 ) of each layer ( 10 ), and wherein a stack ( 100 ) is formed from said layers ( 10 ), such that said first side ( 101 ) of each respective layer ( 10 ) contacts a respective second side ( 102 ) of an adjacent layer ( 10 ), such that said plurality of channels ( 20 ) is formed, wherein said layers ( 10 ) of said stack ( 100 ) are connected, particularly bonded to each other.

14. The method according to claim 13 , wherein said grooves ( 20 ) in said first sides ( 101 ) of said layers ( 10 ) are generated by means of photolithography and subsequent etching.

Assignees

• Eth Zuerich

Inventors

• Studart André R
• Ofner Alessandro
• Schwendimann Pascal

Classifications

• B01F25/31425 Primary

  with a plurality of perforations in the axial and circumferential direction covering the whole surface · CPC title

• B01F23/41

  Emulsifying · CPC title

• B01F33/3021

  the components to be mixed being combined in a single independent droplet, e.g. these droplets being divided by a non-miscible fluid or consisting of independent droplets · CPC title

• B01L3/0241

  Drop counters; Drop formers · CPC title

• B01L3/502746

  characterised by the means for controlling flow resistance, e.g. flow controllers, baffles or throttle valves · CPC title