Body temperature-triggered, in situ forming biomaterials and devices

Patent metadata

Field	Value
Publication number	US-11850328-B2
Application number	US-201716349186-A
Country	US
Kind code	B2
Filing date	Nov 14, 2017
Priority date	Nov 14, 2016
Publication date	Dec 26, 2023
Grant date	Dec 26, 2023

Abstract

Provided herein are thermoresponsive polymer materials and methods of preparation and use thereof. In particular, materials are provided that cure upon exposure to physiologic conditions (e.g., human body temperature) and find use in, for example, orthopedic surgery, bone tissue engineering, and the repair of bone injuries and defects.

First claim

The invention claimed is:

1. A composite material comprising:
(a) an acrylated or methacrylated poly(diol citrate) polymer, wherein the acrylated or methacrylated poly(diol citrate) polymer comprises the formula:

wherein R is H or CH 3 ; wherein x is 1-16;
(b) a thermoresponsive initiator compound, wherein an increase in temperature above a threshold temperature results in radical formation from the thermoresponsive initiator compound, and the radical formation initiates curing of the acrylated or methacrylated poly(diol citrate) polymer into a cured polymer; and
(c) a bioceramic component.

2. The composite material of claim 1 , wherein the bioceramic component is at least 10 wt % of the composite material.

3. The composite material of claim 1 , wherein the bioceramic component comprises hydroxyapatite (HA) and/or β-tricalcium phosphate (β-TCP).

4. The composite material of claim 1 , wherein the acrylated or methacrylated polymer is a liquid and/or is soluble in water and/or organic solvent.

5. The composite material of claim 1 , wherein x is 8, 10, or 12.

6. The composite material of claim 1 , wherein at least 10% of the citric acid monomers of the acrylated or methacrylated poly(diol citrate) polymer display a methacrylate or acrylate.

7. The composite material of claim 6 , wherein at least 90% of the citric acid monomers of the acrylated or methacrylated poly(diol citrate) polymer display a methacrylate or acrylate.

8. The composite material of claim 1 , wherein the thermoresponsive initiator compound is a diazo compound.

9. A composition comprising a cured composite material prepared by thermally-induced curing of the composite material of claim 1 .

10. The composition of claim 9 , wherein thermally-induced curing occurs at a temperature between 32 and 43° C.

11. A method comprising administering the composite material of claim 1 to a bone defect or fracture and allowing the composite material to cure.

Assignees

• Univ Northwestern

Inventors

• Ameer Guillermo A

Classifications

• A61L27/46 Primary

  with phosphorus-containing inorganic fillers · CPC title

• A61K9/00

  Medicinal preparations characterised by special physical form {(nuclear magnetic resonance contrast preparations or magnetic resonance imaging contrast preparations A61K49/18; preparations containing radioactive substances A61K51/12)} · CPC title

• A61K9/0024

  Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue (compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L) · CPC title

• A61K47/32

  Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers {, poly(meth)acrylates, or polyvinyl pyrrolidone} · CPC title

• A61L27/16

  obtained by reactions only involving carbon-to-carbon unsaturated bonds · CPC title