Materials for tissue regeneration

Patent metadata

Field	Value
Publication number	US-10463745-B2
Application number	US-201615573166-A
Country	US
Kind code	B2
Filing date	May 12, 2016
Priority date	May 12, 2015
Publication date	Nov 5, 2019
Grant date	Nov 5, 2019

Abstract

Provided herein are materials for the promotion of tissue regeneration, and methods of promoting tissue regeneration and wound healing therewith. In particular, materials displaying laminin-derived peptide sequences that facilitate cell migration into the material, and methods of use thereof, are provided.

First claim

The invention claimed is:

1. A composition comprising a poly(polyethyleneglycol citrate-co-N-isopropylacrylamide) (PPCN) carrier conjugated to an A5G81-based peptide that promotes cell adhesion, cell proliferation, and/or cell migration into the composition.

2. The composition of claim 1 , wherein the A5G81-based peptide comprises at least 75% sequence similarity with SEQ ID NO: 1.

3. The composition of claim 1 , wherein the peptide and/or PPCN further comprises reactive groups for conjugation.

4. The composition of claim 3 , wherein the peptide comprises a terminal cysteine for conjugation to the PPCN via a N-benzoyl-4-(N-maleimido)-phenylhydrazide (BMPH) linker.

5. A wound dressing comprising a composition of claim 1 .

6. A method of treating a wound comprising applying a wound dressing of claim 5 to the wound.

7. A method of treating a wound comprising applying a composition of claim 1 to the wound.

Assignees

• Univ Northwestern

Inventors

• Zhu Yunxiao
• Cankova Zdravka
• Mrksich Milan
• Ameer Guillermo A

Classifications

• A61P17/02

  for treating wounds, ulcers, burns, scars, keloids, or the like · CPC title

• A61K47/585

  Ion exchange resins, e.g. polystyrene sulfonic acid resin · CPC title

• A61K47/593

  Polyesters, e.g. PLGA or polylactide-co-glycolide · CPC title

• A61L26/008

  Hydrogels or hydrocolloids · CPC title

• A61L2430/00

  Materials or treatment for tissue regeneration · CPC title