Multi-sensor composite right ventricular electrode and fused cardiac rate adaptive pacing method

Patent metadata

Field	Value
Publication number	US-11844948-B2
Application number	US-201817040044-A
Country	US
Kind code	B2
Filing date	Dec 26, 2018
Priority date	Apr 8, 2018
Publication date	Dec 19, 2023
Grant date	Dec 19, 2023

Abstract

Provided is an accurate, fast and long-term stable fused CRAP. The electrode includes a positioning anchor, a silicone catheter, a sensor compartment and a connecting wire. The method monitors physiological information such as blood PPG, blood oxygen saturation, temperature and impedance of blood in the right ventricular cavity, and monitors blood temperature information, which is also a slowly changing metabolic rate, to provide cross-comparison with blood oxygen saturation information, improving monitoring accuracy of blood oxygen saturation. The rapidly changing right ventricular apical impedance information is monitored to improve rapid response ability of CRAP. The LEDs driving current is dynamically adjusted by monitoring the internal temperature of the PPG sensor and the impedance change of the attached biological tissue, which indirectly reflects thickness change of the attached biological tissue, thereby delaying the failure time of the PPG sensor.

First claim

What is claimed is:

1. A multi-sensor composite right ventricular electrode, comprising:
a silicone catheter ( 2 );
a positioning anchor ( 1 ) disposed outside one end of the silicone catheter ( 2 );
a sensor compartment ( 3 ) disposed in the silicone catheter ( 2 ); and
a connecting wire ( 4 ) connected to the sensor compartment ( 3 ),
wherein the sensor compartment ( 3 ) comprises a printed circuit board (PCB), as well as a blood oxygen saturation sensor, a temperature sensor and an impedance sensor that are provided on the PCB, and
wherein the PCB is connected to one end of the connecting wire ( 4 ) via an interface,
wherein the blood oxygen saturation sensor is a dual-wavelength photoplethysmography (PPG) sensor comprising a red LED configured to emit red light, an infrared LED configured to emit infrared light and a photodiode configured to detect reflected red light and/or infrared light, wherein the red LED, the infrared LED and the photodiode are located on a PCB;
wherein the temperature sensor is composed of a thermistor provided on the PCB;
wherein the impedance sensor comprises a pair of titanium metal electrodes arranged on the PCB and configured to form an impedance measurement loop with a biological tissue to be measured, and the titanium metal electrodes are ring-shaped and are embedded on the silicone catheter ( 2 ); and
wherein the thermistor is configured to: sense a temperature of blood outside the silicone catheter ( 2 ) when neither the red LED nor the infrared LED emits light sense operating temperatures of the red LED and the infrared LED when both the red LED and the infrared LED emit light in a time division manner; and prevent the light emitted from LEDs entering the photodiode directly without being reflected by the blood.

2. The multi-sensor composite right ventricular electrode according to claim 1 , wherein the red LED and the infrared LED are connected in parallel or in series to form a unit, and
the unit, the thermistor and the photodiode are sequentially arranged between the pair of titanium metal electrodes.

3. The multi-sensor composite right ventricular electrode according to claim 1 , wherein venous blood oxygen saturation is detected by a dual-wavelength PPG sensor with 660 nm red light and 940 nm infrared light, and is described with an equation (1) or (2):
S p O 2 =α−βR   (1)

S p O 2 =α−βR−γR 2   (2)

where I AC 660 and I AC 940 respectively represent alternating-current components of intensities of the red light and infrared light that are reflected by the blood and are measured by the photodiode; I AC 660 and I AC 940 respectively represent direct-current components of the intensities of the red light and infrared light that are reflected by the blood;

R
=

I
AC
660

⁢

/

⁢

I
DC
660

I
AC
940

⁢

/

⁢

I
DC
940

;

and α, β and γ are all empirical values determined by calibration; and
the equation (1) is a first-order linear relationship between the blood oxygen saturation and R. While the venous blood oxygen saturation does not satisfying the first-order linear relationship, it can be described with a second-order equation (2).

Assignees

• Univ Xi An Jiaotong

Inventors

• Chen Xiang
• Li Jin
• Bai Zhongbo
• Jin Hua
• Qu Quangui
• Zhou Fenghu
• Yun Feng
• Han Ke

Classifications

• A61N1/36585 Primary

  controlled by two or more physical parameters · CPC title

• A61N1/3655

  controlled by body or blood temperature · CPC title

• A61N1/36521

  the parameter being derived from measurement of an electrical impedance · CPC title

• A61B5/02055 Primary

  Simultaneously evaluating both cardiovascular condition and temperature · CPC title

• A61B5/6852 Primary

  Catheters · CPC title