Implantable device with an oxygen sensor and a method of operating an implantable device with an oxygen sensor

Patent metadata

Field	Value
Publication number	US-2016338629-A1
Application number	US-201615162511-A
Country	US
Kind code	A1
Filing date	May 23, 2016
Priority date	May 21, 2015
Publication date	Nov 24, 2016
Grant date	—

Abstract

Embodiments include a method of determining an oxygen content in a bodily tissue or in blood of a human or animal body, wherein a variable representative of oxygen content in the bodily tissue or in the blood is detected at least over one cardiac cycle and is correlated with a contraction state of a heart. Embodiments include a device configured to be inserted into the human or animal body, wherein the device includes at least one sensor unit that detects a signal representative of an oxygen content along a measurement path. Embodiments include a reflector provided on the device, wherein the reflector is arranged in the measurement path between a transmitter and a receiver of the at least one sensor unit to reflect the signal.

First claim

What is claimed is:

1 . A device configured to be inserted into a bodily tissue or in blood of a human or animal body, comprising:
at least one permanently implantable sensor unit that detects a signal that represents an oxygen content along a measurement path,
wherein said at least one permanently implantable sensor unit comprises a transmitter and a receiver; and,
a reflector provided on the device, wherein said reflector is arranged in the measurement path between the transmitter and the receiver of the at least one permanently implantable sensor unit to reflect the signal.

2 . The device as claimed in claim 1 , further comprising a fixation unit, wherein the reflector is arranged on or in said fixation unit configured to permanently fix the device to or in a bodily tissue.

3 . The device as claimed in claim 1 , further comprising an electrode line, wherein the at least one permanently implantable sensor unit is connected to said electrode line, wherein said electrode line is configured to sense electrical activity of a heart to determine cardiac cycle length, and wherein the signal that represents an oxygen content is determined for one or more of a cardiac cycle and phases of a cardiac cycle.

4 . The device as claimed in claim 1 , wherein the permanently implantable sensor unit is configured to be coupled to one or more therapeutic implants.

5 . The device according to claim 1 , further comprising a therapy unit coupled to the at least one permanently implantable sensor unit.

6 . The device as claimed in claim 1 , further comprising a therapy unit, wherein the at least one permanently implantable sensor unit is part of the therapy unit, and wherein the therapy unit comprises one or more of at least one sensing electrode, a therapeutic stimulation electrode and a defibrillation electrode.

7 . The device as claimed in claim 1 , wherein the at least one permanently implantable sensor unit is coupled to an arrangement that is configured to detect a pH value.

8 . The device as claimed in claim 1 , wherein the at least one permanently implantable sensor unit is coupled to a temperature sensor and a heating element.

9 . The device as claimed in claim 1 , wherein the at least one permanently implantable sensor unit is coupled to an arrangement that is configured to detect a contraction state of bodily tissue in a region of the measurement path.

10 . The device as claimed in claim 1 , wherein a maximum myocardial oxygen saturation, a minimum myocardial oxygen saturation, and a difference between minimum and maximum myocardial oxygen saturation are determined from the signal that represents an oxygen content, and therefrom an oxygen extraction rate of a heart is derived.

11 . The device as claimed in claim 10 , wherein the maximum myocardial oxygen saturation, the minimum myocardial oxygen saturation, and the difference between the minimum and the maximum myocardial oxygen saturation are determined over a cardiac cycle, and therefrom a course of the oxygen extraction rate is determined dependent from a heart rate.

12 . The device as claimed in claim 11 , wherein a critical point of the oxygen extraction rate is determined from the course of the measured oxygen extraction rate over the heart rate, wherein the critical point comprises one or more of when the oxygen extraction rate decreases with rising heart rate, when the oxygen extraction rate with rising heart rate transitions into a saturation range, and when the oxygen extraction rate with rising heart rate transitions into a saturation range and at the same time the maximum oxygen saturation value decreases.

13 . The device as claimed in claim 11 , wherein a critical point of the oxygen extraction rate is determined, wherein said critical point comprises when a systolic oxygen saturation falls below a critical reference value or decrease rate of decrease of the oxygen extraction rate exceeds a critical value during the systole.

14 . A cardiac assist system comprising:
a device configured to be inserted into a bodily tissue or in blood of a human or animal body comprising
at least one permanently implantable sensor unit that detects a signal that represents an oxygen content along a measurement path,
wherein said at least one permanently implantable sensor unit comprises a transmitter and a receiver;

at least one therapy unit;
a control unit; and,
a reflector provided on the device, wherein said reflector is arranged in the measurement path between the transmitter and the receiver of the at least one permanently implantable sensor unit to reflect the signal, and
wherein the control unit is configured to optimize one or more stimulation and/or therapy parameters, such that an oxygen saturation in a region of the measurement path with respect to a defined state of load of a heart is set.

15 . The cardiac assist system as claimed in claim 14 , wherein the at least one permanently implantable sensor unit is coupled to an arrangement configured to detect a contraction state of the heart.

16 . The cardiac assist system as claimed in claim 1 , wherein a variable that represents the oxygen content is detected and correlated with a contraction state of the heart.

17 . A method of determining an oxygen content in a bodily tissue or in blood of a human or animal body with a device configured to be inserted into the bodily tissue or in blood of a human or animal body, comprising:
detecting a signal that represents an oxygen content in the tissue or in the blood along a measurement path via at least one permanently implantable sensor unit of the device,
wherein said at least one permanently implantable sensor unit comprises a transmitter and a receiver;
reflecting the signal by a reflector of the device,
wherein the reflector is provided on the device, and
wherein the reflector is arranged in the measurement path between the transmitter and the receiver of the at least one permanently implantable sensor unit;
detecting a variable that represents the oxygen content in the tissue or in the blood at least over one cardiac cycle; and, correlating the variable with a contraction state of the heart.

Assignees

• Biotronik Se & Co Kg

Inventors

• Doerr Thomas

Classifications

• A61B5/14551 Primary

  for measuring blood gases · CPC title

• A61B5/0031

  Implanted circuitry · CPC title

• A61B5/01

  Measuring temperature of body parts {; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue} (clinical contact thermometers G01K13/20) · CPC title

• A61B5/14539

  for measuring pH · CPC title

• A61N1/3987

  characterised by the timing or triggering of the shock · CPC title