Magnetoencephalography (MEG) phantoms for simulating neural activity

Patent metadata

Field	Value
Publication number	US-11839474-B2
Application number	US-202016884672-A
Country	US
Kind code	B2
Filing date	May 27, 2020
Priority date	May 31, 2019
Publication date	Dec 12, 2023
Grant date	Dec 12, 2023

Abstract

A neural phantom device configured and arranged to produce a magnetic field to simulate a neural signal. The neural phantom device includes a driver having a signal source configured to produce a simulated neural signal, and either i) a carrier wave source configured to produce a carrier wave having a frequency of at least 250 Hz or ii) an optical carrier wave source configured to produce an optical carrier wave, wherein the driver is configured to modulate the simulated neural signal using the carrier wave or optical carrier wave to generate a modulated signal. The neural phantom device also includes a phantom configured to receive the modulated signal, demodulate the modulated signal to recover the simulated neural signal, and generate the magnetic field in response to the simulated neural signal.

First claim

What is claimed as new and desired to be protected by Letters Patent of the United States is:

1. A neural phantom device configured and arranged to produce a magnetic field to simulate a neural signal, the neural phantom device comprising:
a driver comprising
a signal source configured to produce a simulated neural signal, and
a carrier wave source configured to produce a carrier wave having a frequency of at least 250 Hz,
wherein the driver is configured to modulate the simulated neural signal using the carrier wave to generate a modulated signal; and

a phantom configured to receive the modulated signal, demodulate the modulated signal to recover the simulated neural signal, and generate the magnetic field in response to the simulated neural signal.

2. The neural phantom device of claim 1 , wherein the carrier wave has a frequency of at least 1 kHz.

3. The neural phantom device of claim 1 , wherein the phantom comprises a rectifier circuit.

4. The neural phantom device of claim 1 , wherein the phantom comprises a full wave rectifier circuit.

5. The neural phantom device of claim 1 , wherein the phantom comprises a printed circuit board and electrical components coupled to the printed circuit board.

6. The neural phantom device of claim 1 , wherein the phantom comprises a plurality of printed circuit boards stacked together and electrical component coupled to the printed circuit boards.

7. The neural phantom device of claim 1 , wherein the neural phantom device comprises a plurality of the phantoms.

8. The neural phantom device of claim 7 , wherein the neural phantom device comprises a plurality of the drivers, wherein each driver is coupled to at least one of the phantoms.

9. A magnetic field measurement system, comprising:
the neural phantom device of claim 1 ;
at least one magnetometer;
at least one memory; and
at least one processor coupled to the at least one memory, the at least one magnetometer, and the neural phantom device.

10. The magnetic field measurement system of claim 9 , wherein the processor is configured to perform actions comprising:
operating the neural phantom device to produce at least one simulated neural signal and generate a magnetic field using the phantom of the neural phantom device in response to the simulated neural signal; and
receiving, from at least one of the at least one magnetometer, a signal in response to the generated magnetic field.

11. A neural phantom device configured and arranged to produce a magnetic field to simulate a neural signal, the neural phantom device comprising:
a driver comprising
a signal source configured to produce a simulated neural signal, and
an optical carrier wave source configured to produce an optical carrier wave,
wherein the driver modulates the simulated neural signal using the optical carrier wave to generate a modulated optical signal; and

a phantom configured to receive the modulated optical signal, demodulate the modulated optical signal to recover the simulated neural signal, and generate the magnetic field in response to the simulated neural signal.

12. The neural phantom device of claim 11 , wherein the driver comprises an electro-optical modulator.

13. The neural phantom device of claim 11 , wherein the driver comprise an optical projector.

14. The neural phantom device of claim 11 , wherein the phantom comprises an array of optical detectors.

15. The neural phantom device of claim 14 , wherein the optical detectors are photodiodes.

16. The neural phantom device of claim 11 , wherein the neural phantom device comprises at least 100 channels.

17. The neural phantom device of claim 11 , further comprising a transparent medium disposed between the driver and the phantom, wherein the transparent medium is configured to simulate a conductivity of components of a user's head.

18. The neural phantom device of claim 11 , wherein the optical carrier wave source is a light source.

19. A magnetic field measurement system, comprising:
the neural phantom device of claim 11 ;
at least one magnetometer;
at least one memory; and
at least one processor coupled to the at least one memory, the at least one magnetometer, and the neural phantom device.

20. The magnetic field measurement system of claim 19 , wherein the processor is configured to perform actions comprising:
operating the neural phantom device to produce at least one simulated neural signal and generate a magnetic field using the phantom of the neural phantom device in response to the simulated neural signal; and
receiving, from at least one of the at least one magnetometer, a signal in response to the generated magnetic field.

Assignees

• Hi Llc

Inventors

• Pratt Ethan
• Mohseni Hooman
• Garber Stephen

Classifications

• A61B5/245 Primary

  specially adapted for magnetoencephalographic [MEG] signals · CPC title

• A61B8/587

  Calibration phantoms · CPC title

• G01R33/26

  using optical pumping · CPC title

• G09B23/30

  Anatomical models {(G09B23/281 - G09B23/288 take precedence)} · CPC title

• A61B2576/026

  for the brain · CPC title