Neuroactive steroids and compositions thereof
US-11643434-B2 · May 9, 2023 · US
US11827634B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11827634-B2 |
| Application number | US-202117549057-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 13, 2021 |
| Priority date | May 31, 2019 |
| Publication date | Nov 28, 2023 |
| Grant date | Nov 28, 2023 |
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The present invention relates to compounds that inhibit NIK and pharmaceutical compositions comprising such compounds and methods of using the same. These compounds and pharmaceutical compositions are envisaged to be useful for preventing or treating diseases such as cancer (such as B-cell malignancies including leukemias, lymphomas and myeloma), inflammatory disorders, autoimmune disorders, immunodermatologic disorders such as palmoplantar pustulosis and hidradenitis suppurativa, and metabolic disorders such as obesity and diabetes.
Opening claim text (preview).
What is claimed: 1. A compound selected from the group consisting of: or a pharmaceutically acceptable salt thereof. 2. The compound of claim 1 , having the following structure or a pharmaceutically acceptable salt thereof. 3. The compound of claim 1 , having the following structure or a pharmaceutically acceptable salt thereof. 4. The compound of claim 1 , having the following structure or a pharmaceutically acceptable salt thereof. 5. The compound of claim 1 , having the following structure or a pharmaceutically acceptable salt thereof. 6. The compound of claim 1 , having the following structure or a pharmaceutically acceptable salt thereof. 7. The compound of claim 1 , having the following structure or a pharmaceutically acceptable salt thereof. 8. The compound of claim 1 , having the following structure or a pharmaceutically acceptable salt thereof. 9. The compound of claim 1 , having the following structure or a pharmaceutically acceptable salt thereof. 10. The compound of claim 1 , having the following structure or a pharmaceutically acceptable salt thereof. 11. The compound of claim 1 , having the following structure or a pharmaceutically acceptable salt thereof. 12. The compound of claim 1 , having the following structure or a pharmaceutically acceptable salt thereof. 13. The compound of claim 1 , having the following structure or a pharmaceutically acceptable salt thereof. 14. The compound of claim 1 , having the following structure or a pharmaceutically acceptable salt thereof. 15. The compound of claim 1 , having the following structure or a pharmaceutically acceptable salt thereof. 16. The compound of claim 1 , having the following structure or a pharmaceutically acceptable salt thereof. 17. The compound of claim 1 , having the following structure or a pharmaceutically acceptable salt thereof. 18. The compound of claim 1 , having the following structure or a pharmaceutically acceptable salt thereof. 19. The compound of claim 1 , having the following structure or a pharmaceutically acceptable salt thereof. 20. A pharmaceutical composition comprising a therapeutically effective amount of at least one compound or pharmaceutically acceptable salt thereof as claimed in claim 1 . 21. The compound of claim 1 , having the following structure 22. The compound of claim 1 , having the following structure 23. The compound of claim 1 , having the following structure 24. The compound of claim 1 , having the following structure 25. The compound of claim 1 , having the following structure 26. The compound of claim 1 , having the following structure 27. The compound of claim 1 , having the following structure 28. The compound of claim 1 , having the following structure 29. The compound of claim 1 , having the following structure 30. The compound of claim 1 , having the following structure 31. The compound of claim 1 , having the following structure
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