Small molecule inhibitors of NF-kB inducing kinase

US11827634B2 · US · B2

Patent metadata
FieldValue
Publication numberUS-11827634-B2
Application numberUS-202117549057-A
CountryUS
Kind codeB2
Filing dateDec 13, 2021
Priority dateMay 31, 2019
Publication dateNov 28, 2023
Grant dateNov 28, 2023

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  1. Title

    What the patent document calls the invention.

  2. Abstract

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  3. Assignees and inventors

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  4. Key dates

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  5. First independent claim

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  6. CPC / IPC classifications

    Technology tags used to group this patent with similar filings.

  7. Citations and related patents

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Abstract

Official abstract text for this publication.

The present invention relates to compounds that inhibit NIK and pharmaceutical compositions comprising such compounds and methods of using the same. These compounds and pharmaceutical compositions are envisaged to be useful for preventing or treating diseases such as cancer (such as B-cell malignancies including leukemias, lymphomas and myeloma), inflammatory disorders, autoimmune disorders, immunodermatologic disorders such as palmoplantar pustulosis and hidradenitis suppurativa, and metabolic disorders such as obesity and diabetes.

First claim

Opening claim text (preview).

What is claimed: 1. A compound selected from the group consisting of: or a pharmaceutically acceptable salt thereof. 2. The compound of claim 1 , having the following structure or a pharmaceutically acceptable salt thereof. 3. The compound of claim 1 , having the following structure or a pharmaceutically acceptable salt thereof. 4. The compound of claim 1 , having the following structure or a pharmaceutically acceptable salt thereof. 5. The compound of claim 1 , having the following structure or a pharmaceutically acceptable salt thereof. 6. The compound of claim 1 , having the following structure or a pharmaceutically acceptable salt thereof. 7. The compound of claim 1 , having the following structure or a pharmaceutically acceptable salt thereof. 8. The compound of claim 1 , having the following structure or a pharmaceutically acceptable salt thereof. 9. The compound of claim 1 , having the following structure or a pharmaceutically acceptable salt thereof. 10. The compound of claim 1 , having the following structure or a pharmaceutically acceptable salt thereof. 11. The compound of claim 1 , having the following structure or a pharmaceutically acceptable salt thereof. 12. The compound of claim 1 , having the following structure or a pharmaceutically acceptable salt thereof. 13. The compound of claim 1 , having the following structure or a pharmaceutically acceptable salt thereof. 14. The compound of claim 1 , having the following structure or a pharmaceutically acceptable salt thereof. 15. The compound of claim 1 , having the following structure or a pharmaceutically acceptable salt thereof. 16. The compound of claim 1 , having the following structure or a pharmaceutically acceptable salt thereof. 17. The compound of claim 1 , having the following structure or a pharmaceutically acceptable salt thereof. 18. The compound of claim 1 , having the following structure or a pharmaceutically acceptable salt thereof. 19. The compound of claim 1 , having the following structure or a pharmaceutically acceptable salt thereof. 20. A pharmaceutical composition comprising a therapeutically effective amount of at least one compound or pharmaceutically acceptable salt thereof as claimed in claim 1 . 21. The compound of claim 1 , having the following structure 22. The compound of claim 1 , having the following structure 23. The compound of claim 1 , having the following structure 24. The compound of claim 1 , having the following structure 25. The compound of claim 1 , having the following structure 26. The compound of claim 1 , having the following structure 27. The compound of claim 1 , having the following structure 28. The compound of claim 1 , having the following structure 29. The compound of claim 1 , having the following structure 30. The compound of claim 1 , having the following structure 31. The compound of claim 1 , having the following structure

Assignees

Inventors

Classifications

  • Drugs for dermatological disorders · CPC title

  • for hyperglycaemia, e.g. antidiabetics · CPC title

  • Anorexiants; Antiobesity agents · CPC title

  • Drugs for disorders of the metabolism (of the blood or the extracellular fluid A61P7/00) · CPC title

  • Immunosuppressants, e.g. drugs for graft rejection · CPC title

Patent family

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Frequently asked questions

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What does patent US11827634B2 cover?
The present invention relates to compounds that inhibit NIK and pharmaceutical compositions comprising such compounds and methods of using the same. These compounds and pharmaceutical compositions are envisaged to be useful for preventing or treating diseases such as cancer (such as B-cell malignancies including leukemias, lymphomas and myeloma), inflammatory disorders, autoimmune disorders, im…
Who is the assignee on this patent?
Janssen Pharmaceutica Nv
What technology area does this patent fall under?
Primary CPC classification C07D487/04. Mapped technology areas include Chemistry & Metallurgy.
When was this patent published?
Publication date Tue Nov 28 2023 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
What related patents are in patentsdb?
We list 6 related publications on this page (citations in our corpus or others sharing the same primary CPC).