System and method for reflective spectroscopy of a cell membrane using a fiber with a plasmonic metasurface

Patent metadata

Field	Value
Publication number	US-11796462-B2
Application number	US-202217888400-A
Country	US
Kind code	B2
Filing date	Aug 15, 2022
Priority date	May 8, 2017
Publication date	Oct 24, 2023
Grant date	Oct 24, 2023

Abstract

An integrated device for the detection of cancerous tissue including an optical fiber configured to receive at a first end modulated infrared light and to conduct the modulated infrared light from the first end to a second end; and a plasmonic metasurface, disposed on the second end of the optical fiber, configured to localize evanescent infrared light to sub-I 00 nanometer distances from the plasmonic metasurface of the optical fiber such that the localized evanescent infrared light penetrates only the membrane portion of a cell held against the second end, wherein the second end is configured to receive reflected light reflected from the membrane portion the cell, the reflected light including spectroscopic information indicative of whether the cell is noncancerous or cancerous.

First claim

What is claimed is:

1. An integrated device for the detection of cancerous tissue, comprising:
an optical fiber configured to receive at a first end modulated infrared light and to conduct the modulated infrared light from the first end to a second end; and
a plasmonic metasurface, disposed on the second end of the optical fiber, configured to localize evanescent infrared light to sub-100 nanometer distances from the plasmonic metasurface of the optical fiber such that the localized evanescent infrared light penetrates a membrane portion of a cell held adjacent the second end, wherein the second end is configured to receive reflected light reflected from the membrane portion the cell, the reflected light including spectroscopic information indicative of whether the cell is noncancerous or cancerous.

2. The integrated device of claim 1 , wherein the plasmonic metasurface is configured to enhance the strength of the localized evanescent infrared light.

3. The integrated device of claim 1 , wherein the plasmonic metasurface is configured to enhance the reflection of the evanescent infrared light.

4. The integrated device of claim 1 , wherein the plasmonic metasurface is tuned to resonate at a vibrational band indicative of one of a cellular trans-membrane protein or a phospholipid.

5. The integrated device of claim 1 , wherein the plasmonic metasurface is includes a plurality of antenna pairs arranged in a periodic pattern.

6. The integrated device of claim 5 , wherein each of the antenna pairs comprises a straight antenna and a bent antenna, the bent antenna including a first leg and a second leg, wherein the first leg is arranged substantially parallel to the straight antenna, and the second leg is arranged at one end of the first leg, extending toward the straight antenna and being substantially perpendicular to first leg and the straight antenna.

7. The integrated device of claim 1 , wherein the optical fiber comprises a plurality of cores, each core including, at an end, a respective plasmonic metasurface.

8. A method for the detection of cancerous tissue, comprising the steps of:
providing an optical fiber configured to conduct infrared light from a first end to a second end, and a plasmonic metasurface, disposed on the second end of the optical fiber, configured to localize evanescent infrared light to sub-I 00 nanometer distances from the plasmonic metasurface;
bringing the plasmonic metasurface into contact with a cell;
transmitting infrared light through the optical fiber, such that the localized evanescent infrared light penetrates the membrane portion of the cell; and
receiving from the second end reflected light reflected from only a membrane portion of the cell, the reflected light including spectroscopic information indicative of whether the cell is noncancerous or cancerous.

9. The method of claim 8 , further comprising the step of analyzing the reflected light to determine if the cell is cancerous or noncancerous.

10. The method of claim 8 , wherein the plasmonic metasurface is configured to enhance the strength of the localized evanescent infrared light.

11. The method of claim 8 , wherein the plasmonic metasurface is configured to enhance the reflection of the evanescent infrared light.

12. The method of claim 8 , wherein the plasmonic metasurface is tuned to resonate at a vibrational band indicative of one of a cellular trans-membrane protein or a phospholipid.

13. The method of claim 8 , wherein the plasmonic metasurface is includes a plurality of antenna pairs arranged in a periodic pattern.

14. The method of claim 13 , wherein each of the antenna pairs comprises a straight antenna and a bent antenna, the bent antenna including a first leg and a second leg, wherein the first leg is arranged substantially parallel to the straight antenna, and the second leg is arranged at one end of the first leg, extending toward the straight antenna and being substantially perpendicular to first leg and the straight antenna.

15. The method of claim 8 , wherein the optical fiber comprises a plurality of cores, each core including, at an end, a respective plasmonic metasurface.

Assignees

• Univ Cornell

Inventors

• Shvets Gennady
• Gupta Shourya Dutta

Classifications

• G01N33/5759

  involving compounds localised on the membrane of tumour or cancer cells · CPC title

• G01N21/3563 Primary

  for analysing solids; Preparation of samples therefor · CPC title

• G01N21/554 Primary

  detecting the surface plasmon resonance of nanostructured metals, e.g. localised surface plasmon resonance · CPC title

• G01N2021/3595

  using FTIR · CPC title

• G01N2201/08

  Optical fibres; light guides · CPC title