Single cycle replicating adenovirus vectors
US-11279953-B2 · Mar 22, 2022 · US
Single cycle replicating adenovirus vectors
US11795477B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11795477-B2 |
| Application number | US-202217671294-A |
| Country | US |
| Kind code | B2 |
| Filing date | Feb 14, 2022 |
| Priority date | Mar 6, 2008 |
| Publication date | Oct 24, 2023 |
| Grant date | Oct 24, 2023 |
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- Title
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Abstract
Official abstract text for this publication.
This document relates to adenovirus vectors and methods and materials related to using adenovirus vectors. For example, viruses, nucleic acid molecules encoding viruses, cell lines containing viral vectors, and methods for using viruses to deliver nucleic acid to cells in vitro or in vivo are provided. Methods and materials for using adenovirus vectors to induce immune responses and to treat cancer also are provided.
First claim
Opening claim text (preview).
What is claimed is: 1. A method for inducing an immune response against an antigen in a mammal, wherein said method comprises: (a) providing an initial administration of a single cycle replicating adenovirus to said mammal under conditions wherein said adenovirus infects a cell of said mammal and replicates within said cell, wherein said cell does not produce new infectious virions following infection with said adenovirus, wherein said adenovirus comprises an adenovirus polypeptide and lacks at least a portion of a nucleic acid sequence that encodes said adenovirus polypeptide, wherein when said adenovirus lacks at least a portion of a nucleic acid sequence that encodes a fiber protein, said adenovirus comprises a fiber protein having wild-type specificity, wherein said adenovirus comprises a nucleic acid sequence encoding said antigen, and wherein expression of said antigen in said cell leads to induction of said immune response, and (b) providing a repeated administration of said single cycle replicating adenovirus to said mammal. 2. The method of claim 1 , wherein said mammal is a human. 3. The method of claim 1 , wherein said antigen is a tumor antigen. 4. The method of claim 3 , wherein said tumor antigen is NY-ESO, EBV-LMP, or a papilloma virus antigen. 5. The method of claim 1 , wherein said cell is an epithelial cell, a tumor cell, a hematopoietic cell, or an antigen presenting cell. 6. The method of claim 1 , wherein said adenovirus polypeptide is a fiber protein, a V protein, hexon, penton-base, or pIII.
Assignees
Inventors
Classifications
Medicinal preparations containing antigens or antibodies (materials for immunoassay G01N33/53) · CPC title
- C12N15/86Primary
Viral vectors · CPC title
Viral antigens · CPC title
oral/gastrointestinal · CPC title
viral genome or elements thereof as genetic vector · CPC title
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Frequently asked questions
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- What does patent US11795477B2 cover?
- This document relates to adenovirus vectors and methods and materials related to using adenovirus vectors. For example, viruses, nucleic acid molecules encoding viruses, cell lines containing viral vectors, and methods for using viruses to deliver nucleic acid to cells in vitro or in vivo are provided. Methods and materials for using adenovirus vectors to induce immune responses and to treat ca…
- Who is the assignee on this patent?
- Mayo Found Medical Education & Res
- What technology area does this patent fall under?
- Primary CPC classification C12N15/86. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Oct 24 2023 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 9 related publications on this page (citations in our corpus or others sharing the same primary CPC).