Adenovirus vectors and methods for using adenovirus vectors
US-11149286-B1 · Oct 19, 2021 · US
Single cycle replicating adenovirus vectors
US11279953B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11279953-B2 |
| Application number | US-202016863705-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 30, 2020 |
| Priority date | Mar 6, 2008 |
| Publication date | Mar 22, 2022 |
| Grant date | Mar 22, 2022 |
How to read this patent
A practical reading order for non-experts. Skip the full description unless you need deep technical detail.
- Title
What the patent document calls the invention.
- Abstract
A short plain-language summary of the technical disclosure.
- Assignees and inventors
Who owns or filed the patent and who is credited as inventor.
- Key dates
Filing, priority, publication, and grant dates set the timeline.
- First independent claim
The legal scope of protection — read this for what is actually claimed.
- CPC / IPC classifications
Technology tags used to group this patent with similar filings.
- Citations and related patents
Prior art links and similar publications in this corpus.
Abstract
Official abstract text for this publication.
This document relates to adenovirus vectors and methods and materials related to using adenovirus vectors. For example, viruses, nucleic acid molecules encoding viruses, cell lines containing viral vectors, and methods for using viruses to deliver nucleic acid to cells in vitro or in vivo are provided. Methods and materials for using adenovirus vectors to induce immune responses and to treat cancer also are provided.
First claim
Opening claim text (preview).
What is claimed is: 1. A single cycle replicating adenovirus, wherein when said adenovirus is administered to a mammal, said adenovirus infects a cell of said mammal and replicates within said cell, wherein said cell does not produce new infectious virions following infection with said adenovirus, wherein said adenovirus comprises an adenovirus polypeptide and lacks at least a portion of a nucleic acid sequence that encodes said adenovirus polypeptide, wherein when said adenovirus lacks at least a portion of a nucleic acid sequence that encodes a fiber protein, said adenovirus comprises a fiber protein having wild-type specificity, wherein said adenovirus comprises a nucleic acid sequence encoding an antigen, and wherein expression of said antigen in said cell leads to induction of an immune response within said mammal. 2. The adenovirus of claim 1 , wherein said mammal is a human. 3. The adenovirus of claim 1 , wherein said antigen is a tumor antigen. 4. The adenovirus of claim 3 , wherein said tumor antigen is NY-ESO, EBV-LMP, or a papilloma virus antigen. 5. The adenovirus of claim 1 , wherein said cell is an epithelial cell, a tumor cell, a hematopoietic cell, or an antigen presenting cell. 6. The adenovirus of claim 1 , wherein said adenovirus polypeptide is a fiber protein, a V protein, hexon, penton-base, or pIII.
Assignees
Inventors
Classifications
Medicinal preparations containing antigens or antibodies (materials for immunoassay G01N33/53) · CPC title
oral/gastrointestinal · CPC title
Immunostimulants · CPC title
- C12N15/86Primary
Viral vectors · CPC title
Antineoplastic agents · CPC title
Patent family
Related publications grouped by family.
External sources
Frequently asked questions
Answers are generated from the same data shown on this page.
- What does patent US11279953B2 cover?
- This document relates to adenovirus vectors and methods and materials related to using adenovirus vectors. For example, viruses, nucleic acid molecules encoding viruses, cell lines containing viral vectors, and methods for using viruses to deliver nucleic acid to cells in vitro or in vivo are provided. Methods and materials for using adenovirus vectors to induce immune responses and to treat ca…
- Who is the assignee on this patent?
- Mayo Found Medical Education & Res
- What technology area does this patent fall under?
- Primary CPC classification C12N15/86. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Mar 22 2022 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 4 related publications on this page (citations in our corpus or others sharing the same primary CPC).