Continuous production of active pharmaceutical ingredients

Patent metadata

Field	Value
Publication number	US-11779859-B2
Application number	US-202117546305-A
Country	US
Kind code	B2
Filing date	Dec 9, 2021
Priority date	Dec 9, 2020
Publication date	Oct 10, 2023
Grant date	Oct 10, 2023

Abstract

The present invention is directed to a method of producing active pharmaceutical ingredients (APIs). The method includes subjecting a reaction mixture with an API precursor to solvent extraction to produce a reactant stream with the API precursor. The method includes concentrating the API precursor in the reactant stream using at least one membrane. The method includes carrying out a reaction in a membrane reactor. The method includes separating the API precursor from the reaction stream using a separator. The method includes crystallizing the API precursor using a crystallizer to produce APIs.

First claim

The invention claimed is:

1. A method of producing active pharmaceutical ingredients (APIs), comprising:
(a) subjecting a reaction mixture with an API precursor to solvent extraction to produce a reactant stream with the API precursor;
(b) concentrating the API precursor in the reactant stream using at least one membrane;
(c) carrying out a reaction in a membrane reactor;
(d) separating the API precursor from the reaction stream using a separator; and
(e) crystallizing the API precursor using a crystallizer to produce APIs, wherein at least one of a reactor for performing step (a), the separator of step (d), or the crystallizer of step (e) is a membrane-based device.

2. The method of claim 1 , comprising heating, cooling, and/or quenching of solutions containing active pharmaceutical ingredients using solid hollow fiber heat exchangers.

3. The method of claim 2 , wherein the heat exchangers are membrane-based.

4. The method of claim 1 , comprising removing impurities from organic process streams using membrane adsorbers.

Assignees

• New Jersey Inst Technology

Inventors

• Sirkar Kamalesh

Classifications

• B01D63/02

  Hollow fibre modules · CPC title

• B01D61/362

  Pervaporation · CPC title

• B01D9/0059 Primary

  General arrangements of crystallisation plant, e.g. flow sheets · CPC title

• B01D9/02

  from solutions · CPC title

• B01D11/0492

  Applications, solvents used · CPC title