Silicone hydrogels comprising N-alkyl methacrylamides and contact lenses made thereof

Patent metadata

Field	Value
Publication number	US-11754754-B2
Application number	US-202117403973-A
Country	US
Kind code	B2
Filing date	Aug 17, 2021
Priority date	Jul 6, 2016
Publication date	Sep 12, 2023
Grant date	Sep 12, 2023

Abstract

The present invention relates to silicone hydrogels exhibiting desired combinations of physical and mechanical properties, formed from a reactive monomer mixture comprising at least one N-alkyl methacrylamide, and at least one silicone-containing component. These silicone hydrogels may also contain hydrophilic components, crosslinking agents and toughening monomers. These silicone hydrogels are useful in preparing biomedical devices, ophthalmic lenses, and contact lenses.

First claim

What is claimed is:

1. A process for making a composite contact lens, comprising:
(a) dosing a first silicone hydrogel formulation containing at least one N-alkyl methacrylamide and at least one silicone-containing component into a first mold,
(b) partially curing the first silicone hydrogel formulation into a gel,
(c) dosing a second silicone hydrogel formulation into the first mold
(d) allowing time for the second silicone hydrogel formulation to imbibe into the gel,
(e) placing a second mold on top of the first mold, and
(f) fully curing the combination to form the composite contact lens,

wherein the composite contact lens contains a central region comprised of a first silicone hydrogel derived from the first silicone hydrogel formulation and a peripheral region comprised of a second silicone hydrogel derived from the second silicone hydrogel formulation, and
wherein the first silicone hydrogel has a modulus of at least about 1000 psi and a water content of at least about 10%.

2. A process for making a composite contact lens, comprising:
(a) dosing a first silicone hydrogel formulation containing at least one N-alkyl methacrylamide and at least one silicone-containing component into a first mold,
(b) partially curing the first silicone hydrogel formulation into a gel,
(c) dosing a second silicone hydrogel formulation into the first mold
(d) allowing time for the second silicone hydrogel formulation to imbibe into the gel,
(e) placing a second mold on top of the first mold, and
(f) fully curing the combination to form the composite contact lens,

wherein the composite contact lens contains a central region comprised of a first silicone hydrogel that is a non-ionic silicone hydrogel derived from the first silicone hydrogel formulation and a peripheral region comprised of a second silicone hydrogel derived from the second silicone hydrogel formulation, and wherein the first silicone hydrogel has a modulus of about 140 to about 2000 psi and a water content of about 20 to about 50%.

3. The process of any one of claims 1 to 2 wherein the peripheral region exhibits a lower modulus than the central region.

4. The process of claim 1 wherein the central region exhibits a modulus between about 10,000 psi and about 200,000 psi and the peripheral region exhibits a modulus between about 50 psi and about 300 psi.

5. The process of claim 3 wherein the first and second silicone hydrogels comprise water contents within about 5 weight percent of one another.

6. The process of claim 3 wherein the central region is encapsulated by the peripheral region.

Assignees

• Johnson & Johnson Vision Care

Inventors

• Alli Azaam
• Sinha Dola

Classifications

• G02B1/043 Primary

  Contact lenses · CPC title

• C08F290/068 Primary

  Polysiloxanes · CPC title

• C08F283/122 Primary

  on to saturated polysiloxanes containing hydrolysable groups, e.g. alkoxy-, thio-, hydroxy- · CPC title

• C08J3/075

  Macromolecular gels · CPC title

• G02C7/049

  Contact lenses having special fitting or structural features achieved by special materials or material structures · CPC title