Series of skin-whitening (lightening) compounds

Patent metadata

Field	Value
Publication number	US-11739040-B2
Application number	US-202117194617-A
Country	US
Kind code	B2
Filing date	Mar 8, 2021
Priority date	Jul 21, 2008
Publication date	Aug 29, 2023
Grant date	Aug 29, 2023

Abstract

The present invention is directed to inhibitors of tyrosinase, pharmaceutical compositions comprising such tyrosinase inhibitors, and methods of making and using the same. Specifically, included in the present invention are compositions of matter comprised of at least one 2,4-dihydroxybenzene analog, which inhibit the activity of tyrosinase and which inhibit the overproduction of melanin.

First claim

The invention claimed is:

1. A compound of Formula V:

or a pharmaceutically acceptable salt thereof, wherein:
R 1 is H;
Bn is a benzyl; and
R′ is 1 to 3 moieties (R′, R″, R′″) independently selected from the group consisting of a C 1 -C 10 alkoxy group or a hydroxyl group.

2. A composition comprising the compound of claim 1 and a pharmaceutically or cosmetically acceptable carrier.

Assignees

• Unigen Inc

Inventors

• Nandy Sandip K
• Liu Jiyun
• Nesterov Alexandre Mikhailovitch
• Hertel Carmen
• Papmapiya Abeysinghe Arrachchigae

Classifications

• A23B2/742

  Organic compounds containing oxygen · CPC title

• C07C43/295 Primary

  containing hydroxy or O-metal groups · CPC title

• A23B7/154 Primary

  Organic compounds; Microorganisms; Enzymes · CPC title

• A23L3/3481

  Human Necessities · mapped topic

• A61K8/345

  containing more than one hydroxy group · CPC title