Properties and parameters of novel biodegradable metallic alloys

Patent metadata

Field	Value
Publication number	US-11732334-B2
Application number	US-201816500928-A
Country	US
Kind code	B2
Filing date	Apr 12, 2018
Priority date	Apr 12, 2017
Publication date	Aug 22, 2023
Grant date	Aug 22, 2023

Abstract

The invention relates to biodegradable, metal alloys, methods for their preparation and applications for their use. The alloys include magnesium and other components, such as, yttrium, calcium, zirconium, and zinc. These elements are alloyed together in specific combinations and amounts in order to achieve an alloy having desired properties and characteristics. In certain embodiments, strontium or cerium may be included as an additive. The resulting alloys are particularly suitable for forming various medical devices for implantation into the body of a patient.

First claim

The invention claimed is:

1. A biodegradable medical implant device, comprising:
a biodegradable, extruded metal alloy, consisting of:
about 4.0 weight percent of yttrium;
from about 0.5-0.6 weight percent of calcium;
from about 0.6-1.0 weight percent of zirconium;
about 2.0 weight percent of zinc; and
a balance of magnesium including impurities, based on the total weight of the composition,
wherein the biodegradable, extruded metal alloy is a solid solution, and intermetallic phases are precluded other than a long period stacking order phase Mg 12 YZn, and
wherein the metal alloy has ultimate tensile strength from about 375 to about 410 MPa and yield tensile strength from about 335 to about 345 MPa, and exhibits proliferation of cells and corresponding osteogenic differentiation.

2. The medical implant device of claim 1 , wherein the calcium constitutes about 0.6 weight percent and the zirconium constitutes about 1.0 weight percent.

3. The medical implant device of claim 1 , wherein the zirconium constitutes about 0.6 weight percent.

4. The medical implant device of claim 1 , wherein the impurities comprise one or more of iron, nickel, and copper.

5. The medical implant device of claim 1 , wherein the impurities constitute 20 ppm or less.

6. The medical implant device of claim 1 , wherein the metal alloy has elongation about 15%.

Assignees

• Univ Pittsburgh Commonwealth Sys Higher Education

Inventors

• Kumta Prashant N

Classifications

• C22C23/06 Primary

  with a rare earth metal as the next major constituent · CPC title

• A61L27/58 Primary

  Materials at least partially resorbable by the body · CPC title

• A61L27/047

  Other specific metals or alloys not covered by A61L27/042 - A61L27/045 or A61L27/06 · CPC title

• C22C23/04

  with zinc or cadmium as the next major constituent · CPC title

• A61L31/148

  Materials at least partially resorbable by the body · CPC title