Blood purification membrane, method for manufacturing blood purification membrane, and dialysis device
US-2016199789-A1 · Jul 14, 2016 · US
Tangential flow depth filtration systems and methods of filtration using same
US11643628B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11643628-B2 |
| Application number | US-202117218563-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 31, 2021 |
| Priority date | Mar 8, 2018 |
| Publication date | May 9, 2023 |
| Grant date | May 9, 2023 |
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- Title
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Abstract
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The present disclosure relates to hollow fiber tangential flow filters, including hollow fiber tangential flow depth filters, for various applications, including bioprocessing and pharmaceutical applications, systems employing such filters, and methods of filtration using the same.
First claim
Opening claim text (preview).
What is claimed is: 1. A method of filtering a fluid, comprising: passing a fluid through a tangential flow depth filter (TFDF) comprising a thick-walled hollow fiber with a porous wall formed by assembling a plurality of filaments into a tubular shape; wherein the fluid is passed through the TFDF in a pulsatile manner, the pulsatile manner comprising at least about 200 cycles per minute. 2. The method of claim 1 , wherein a density of the hollow fiber is between about 51% and about 56% of the density of an equivalent solid volume of the hollow fiber. 3. The method of claim 1 , wherein the porous wall further comprises a plurality of particles. 4. The method of claim 3 , wherein at least one of the plurality of filaments and the plurality of particles are mono-component. 5. The method of claim 3 , wherein at least one of the plurality of filaments and the plurality of particles are multi-component. 6. The method of claim 1 , further comprising: culturing the fluid within a lumen of the hollow fiber; and clarifying the fluid within the lumen. 7. A method of filtering a fluid, comprising: flowing a fluid through a tangential flow depth filter (TFDF) in a pulsatile manner, the TFDF comprising a thick-walled hollow fiber with a porous wall; wherein the pulsatile manner comprises at least about 200 cycles per minute. 8. The method of claim 7 , wherein the hollow fiber comprises a density between about 51% and about 56% of the density of an equivalent solid volume of the hollow fiber. 9. The method of claim 7 , further comprising pumping the fluid via a peristaltic pump. 10. The method of claim 7 , wherein the pulsatile manner comprises at least about 2000 cycles per minute. 11. The method of claim 7 , wherein the hollow fiber comprises a porous wall formed by assembling a plurality of filaments into a tubular shape. 12. The method of claim 7 , wherein the hollow fiber comprises a porous wall formed by assembling a plurality of particles into a tubular shape. 13. The method of claim 7 , further comprising: culturing the fluid within a lumen of the hollow fiber; and clarifying the fluid within the lumen. 14. A method of filtering a fluid, comprising: flowing a fluid through a tangential flow depth filter (TFDF) comprising a thick-walled hollow fiber such that the flowing fluid comprises a Reynold's number at a feed of the hollow fiber greater than about 2263. 15. The method of claim 14 , wherein the hollow fiber comprises a density between about 51% and about 56% of the density of an equivalent solid volume of the hollow fiber. 16. The method of claim 14 , wherein flowing the fluid comprises a flux of at least about 400 LMH. 17. The method of claim 14 , further comprising: culturing the fluid within a lumen of the hollow fiber; and clarifying the fluid within the lumen. 18. The method of claim 14 , wherein the hollow fiber comprises a porous wall formed by assembling a plurality of filaments and a plurality of particles into a tubular shape.
Assignees
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Classifications
Pore size · CPC title
Polyethylene · CPC title
Polypropylene · CPC title
by sintering · CPC title
Polyesters · CPC title
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Frequently asked questions
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- What does patent US11643628B2 cover?
- The present disclosure relates to hollow fiber tangential flow filters, including hollow fiber tangential flow depth filters, for various applications, including bioprocessing and pharmaceutical applications, systems employing such filters, and methods of filtration using the same.
- Who is the assignee on this patent?
- Repligen Corp
- What technology area does this patent fall under?
- Primary CPC classification C12M29/16. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue May 09 2023 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 3 related publications on this page (citations in our corpus or others sharing the same primary CPC).